Spicamycin, a New Differentiation Inducer of Mouse Myeloid Leukemia Cells (Ml) and Human Promyelocytic Leukemia Cells (HL-60)

スポンサーリンク

概要

• 論文の詳細を見る

• A new antibiotic was obtained from the culture broth of Streptomyces alanosinicus 879-MT3, and the name spicamycin was given. Spicamycin had a marked effect on the induction of differentiation of human promyelocytic leukemia cells (HL-60) as well as mouse myeloid leukemia cells (Ml). Its structure was elucidated by degradative studies and 1H and 13C NMR spectral analysis as shown in Fig. 1.

• 社団法人 日本農芸化学会の論文

著者

• HAYAKAWA YOICHI

  Institute of Molecular and Cellular Biosciences, The University of Tokyo

• SETO Haruo

  Institute of Molecular and Cellular Biosciences, The University of Tokyo

• Shimazu A

  Institute Of Applied Microbiology The University Of Tokyo

• NAKAYAMA Hiroshi

  Institute of Applied Microbiology, The University of Tokyo

• SHIMAZU Akira

  Institute of Applied Microbiology, The University of Tokyo

• OTAKE Noboru

  Institute of Applied Microbiology, The University of Tokyo

• NAKAGAWA Masaya

  Institute of Applied Microbiology, The University of Tokyo

• KAWAI Hiroyuki

  Applied Bioscience Laboratory, Kirin Brewery Co., Ltd.

• TANABE Kozo

  Applied Bioscience Laboratory, Kirin Brewery Co., Ltd.

• Nakagawa M

  Institute Of Applied Microbiology The University Of Tokyo:(present Office)pharmaceutical Laboratory

• Otake Noboru

  Institute Of Applied Microbiology The University Of Tokyo

• Hayakawa Yoichi

  Institute Of Applied Microbiology The University Of Tokyo

• Seto Haruo

  Institute Of Applied Microbiology The University Of Tokyo

• Shimazu Akira

  Institute Of Applied Microbiology The University Of Tokyo

• Nakayama Hiroshi

  Institute Of Applied Microbiology The University Of Tokyo

関連論文

• Oximidine III, a New Antitumor Antibiotic against Transformed Cells from Pseudomonas sp. II. Structure Elucidation
• Oximidine III, a New Antitumor Antibiotic against Transformed Cells from Pseudomonas sp. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activity
• Neuroprotectins A and B, Bicyclohexapeptides Protecting Chick Telencephalic Neurons from Excitotoxicity : II. Structure Determination
• Byssochlamysol, a New Antitumor Steroid against IGF-1-dependent Cells from Byssochlamys nivea II. Physico-chemical Properties and Structure Elucidation
• Byssochlamysol, a New Antitumor Steroid against IGF-1-dependent Cells from Byssochlamys nivea I, taxonomy, Fermentation, Isolation and Biological Activity
• Structure of Aspochalasin H, a New Member of the Aspochalasin Family
• A Novel Neuronal Cell Protecting Substance, Halxazone, Produced by Streptomyces halstedii
• Neuroprotectins A and B, Bicyclohexapeptides Protecting Chick Telencephalic Neuronal Cells from Excitotoxicity : I. Fermentation, Isolation, Physico-chemical Properties and Biological Activity
• Ammocidin, a New Apoptosis Inducer in Ras-dependent Cells from Saccharothrix sp. : II. Physico-chemical Properties and Structure Elucidation
• Ammocidin, a New Apoptosis Inducer in Ras-dependent Cells from Saccharothrix sp. : I. Production, Isolation and Biological Activity
• Selective Cytotoxicity and Stereochemistry of Aspochalasin D
• Phoenistatin, A New Gene Expression-Enhancing Substance Produced by Acremonium fusigerum
• Rustmicin, a New Macrolide Antibiotic Active Against Wheat Stem Rust Fungus(Organic Chemistry)
• Isolation and Structural Determination of a New Antibiotic Curromycin B
• Spicamycin, a New Differentiation Inducer of Mouse Myeloid Leukemia Cells (Ml) and Human Promyelocytic Leukemia Cells (HL-60)
• Propanosine (K-76), a New Antibiotic Active against Valsa ceratosperma, the Pathogen of Apple Canker Disease
• Taxonomy of Producing Organism, and Production, Isolation, Physico-chemical Properties and Biological Activities of Cirratiomycin A and B
• Phenazostatin C, a New Diphenazine with Neuronal Cell Protecting Activity from Streptomyces sp.
• New Diphenazines with Neuronal Cell Protecting Activity, Phenazostatins A and B, Produced by Streptomyces sp.
• Hydrogenated Amorphous Silicon/Crystalline Silicon Double Heterojunction X-Ray Sensor
• Bacillus subtilis ypgA Gene Is fni, a Nonessential Gene Encoding Type 2 Isopentenyl Diphosphate Isomerase
• Diheteropeptin, a Novel Substance with TGF-β-like Activity, Produced by a Fungus, Diheterospora chlamydosporia : II. Physico-chemical Properties and Structure Elucidation
• Diheteropeptin, a New Substance with TGF-β-like Activity, Produced by a Fungus, Diheterospora chlamydosporia : I. Production, Isolation and Biological Activities
• Structure of a New Anthracycline, Cinerubin Y, Produced by a Blocked Mutant of Streptomyces violaceochromogenes Transformed by pIJ702(Organic Chemistry)
• Structure of a New Antibiotic Oxaspirol A
• Structure of a New Antibiotic, Terrecyclol, from Aspergillus terreus Thorn
• The Biosynthesis of Terrecyclic Acid A, a Novel Sesquiterpene Antibiotic
• A New Depsipeptide Antibiotic, Citropeptin(Microbiology & Fermentation Industry)
• A New Depsipeptide Antibiotic, Variapeptin(Microbiology & Fermentation Industry)
• Rasfonin, a New Apoptosis Inducer in ras-dependent Cells from Talaromyces sp.
• Cytovaricin B, a New Inhibitor of JAK-STAT Signal Transduction Produced by Streptomyces torulosus
• Screening of Microbial Products Modifying the Action of Lepin (Obese Gene Product by a Biosensor)
• Microbial and Chemical Conversion of Antibiotic K-41. I. Isolation and Identification of Conversion Product
• Contribution of N-terminal and Loop Regions of GBP to the Interaction with Epidermal Growth Factor Receptor
• FUNCTION OF INSECT CYTOKINE GBP IN EMBRYOGENESIS OF CABBAGE ARMYWORM, MAMESTRA BRASSICAE(Biochemistry,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• STAGE SPECIFIC AND REGION SPECIFIC EXPRESSION OF INSECT CYTOKINE GBP IN EMBRYO OF CABBAGE ARMYWORM, MAMESTRA BRASSICAE(Biochemistry & Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
• Nucleotide Sequences of Genes Encoding Allosamidin-sensitive and -insensitive Chitinases Produced by Allosamidin-producing Streptomyces(Biochemistry & Molecular Biology)
• A Role of Osteoclasts in the Repair Process After Bone Defect with Special Reference to Carbonic Anhydrase
• Effect of in vivo Administration of Thyroid Hormone on Phosphate Uptake of Brush Border Membrane Vesicles from Kidney Cortex of Rachitic Rats
• A New Screening Method for C-P Compound Producing Organisms by the Use of Phosphoenolpyruvate Phosphomutase(Biological Chemistry)
• Cloning and Expression in Escherichia coli of 2-Hydroxypropylphosphonic Acid Epoxidase from the Fosfomycin-producing Organism, Pseudomonas syringae PB-5123
• Nucleotide Sequence of Fortimicin KL1 Methyltransferase Gene Isolated from Micromonospora olivasterospora, and Comparison of Its Deduced Amino Acid Sequence with Those of Methyltransferases Involved in the Biosynthesis of Bialaphos and Fosfomycin
• Solution Structure of an Insect Growth Factor Peptide GBP and its EGF Activity
• Structure-antitumor Activity Relationship of Semi-synthetic Spicamycin Derivatives
• Absolute Configuration of Spicamycin, an Antitumor Antibiotic Produced by Streptomyces alanosinicus
• Synthesis and Antitumor Activities of Glycine-exchanged Analogs of Spicamycin
• Structures of New Saponins Isolated from Bupleurum kunmingense Y. Li et S. L. Pan(Organic Chemistry)
• Isolation of Triterpenoid Glycosides (Saikosaponins) from Bupleurum polyclonum Y. Li et S. L. Pan and Their Chemical Structures(Organic Chemistry)
• Stachybocins, Novel Endothelin Receptor Antagonists, Produced by Stachybotrys sp.M6222 II.Structure Determination of Stachybocins A, Band C
• Analysis in the course of polydnavirus replication in ovarian calyx cells of the parasitoid wasp, Cotesia kariyai (Hymenoptera: Braconidae)
• Isolation and Structure of Isobutyrylleucanicidin Produced by Streptomyces halstedii
• The Structure of Leucanicidin, a Novel Insecticidal Macrolide Produced by Streptomyces halstedii
• Isolation of Abikoviromycin and Dihydroabikoviromycin as Inhibitors of Polyketide Synthase Involved in Melanin Biosynthesis by Colletotrichum lagenarium
• Isolation and Characterization of 2-Nitroimidazole Produced by Streptomyces Species as an Inhibitor of Both Carbonic Anhydrase and Shell Formation in the Barnacle Balanus amphitrite
• Trichostatin D, a New Inducer of Phenotypic Reversion in Transformed Cells
• Novel Antibiotics Pyrisulfoxin A and B Produced by Streptomyces californicus
• Detection of the Mevalonate Pathway in Streptomyces Species by Utilization of the 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Gene
• Carquinostatin B, a New Neuronal Cell-protecting Substance Produced by Streptomyces exfoliatus
• A Novel Neuronal Cell Protecting Substance, Naphthomycinol, Produced by Streptomyces sp. PF7
• A Novel Neuronal Cell Protecting Substance, Espicufolin, Produced by Streptomyces sp. cu39
• Cinnatriacetins A and B, New Antibacterial Triacetylene Derivatives from the Fruiting Biodies of Fistulina hepatica
• New Ravidomycin Analogues, FE35A and FE35B, Apotosis Inducers Produced by Streptomyces rochei
• A Novel Neuronal Cell Protecting Substance, Aestivophoenin C, Produced by Streptomyces purpeofuscus
• 6-Hydroxytetrangulol, a New CPP32 Protease Inducer Produced by Streptomyces sp.
• A Novel Substance with TGF-β like Activity, Diheteropeptin, Produced by a Fungus, Diheterospora sp.
• Isolation and Structure Elucidation of Novel Neuronal Cell Protecting Substances, Carazomadurins A and B Produced by Actinomadura madurae
• Studies on New Antitumor Antibiotics, Leptofuranins A, B, C and D II. Physicochemical Properties and Structure Elucidation
• Studies on New Antitumor Antibiotics, Leptofuranins A, B, C and D I. Taxonomy, Fermentation, Isolation and Biological Activities
• Diazaphilonic Acid, a New Azaphilone with Telomerase Inhibitory Activity
• Synthesis of 4'-O-Acylanthracyclines(Organic Chemistry)
• A Neuronal Cell Protecting Substance, 4-Demethoxymicigazone, produced by Streptomyces halstedii
• Apoptolidin, a New Apoptosis Inducer in Transformed Cells from Nocardiopsis sp.
• Novel Neuronal Cell Protecting Substances, Aestivophoenins A and B, Produced by Streptomyces purpeofuscus
• A New Neuronal Cell Protecting Substance, Lavanduquinocin, Produced by Streptomyces viridochromogenes
• Formobactin, a Novel Radical Scavenging and Neuronal Cell Protecting Substance from Nocardia sp
• Thiopeptide Non-producing Streptomyces Species Carry the tipA Gene : A Clue to Its Function
• Comparison of Two C-P Bond-forming Enzymes Involved in the Biosynthesis of Bialaphos(Biological Chemistry)
• Major Anthocyanin of the Flowers of Hibiscus (Hibiscus rosa-sinensis L.)(Organic Chemistry)
• Growth-phase Dependent Expression of the Mevalonate Pathway in a Terpenoid Antibiotic-producing Streptomyces Strain(Microbiology & Fermentation Technology)
• Cloning of a Gene Cluster Encoding Enzymes Responsible for the Mevalonate Pathway from a Terpenoid-antibiotic-producing Streptomyces Strain(Microbiology & Fermentation Technology)
• The Structure of Enacyloxin II, a Novel Linear Polyenic Antibiotic Produced by Gluconobacter sp. W-315(Organic Chemistry)
• Fluorinated Blasticidin S(Organic Chemistry)
• Crystal Structure of 1-Deoxy-D-xylulose 5-phosphate Reductoisomerase Complexed with Cofactors : Implications of a Flexible Loop Movement upon Substrate Binding
• IDENTIFICATION AND CLONING OF GROWTH-BLOCKING PEPTIDE (GBP) RECEPTOR(Biochemistry,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• Studies on the Biosynthesis of Terpenoidal Compounds Produced by Actinomycetes 2. Biosynthesis of Carquinostatin B via the Non-mevalonate pathway in Streptomyces exfoliatus
• Construction and Characterization of Escherichia coli Disruptants Defective in the yaeM Gene
• Purification of Primary Structure of Proteinous α-Amylase Inhibitor from Streptomyces chartreusis
• The Structures of Cirratiomycin A and B, the New Peptide Antibiotics
• The Structures of Myocotrienins I. and II, a Novel Class of Ansamycin Antibiotic
• Isolation and Structures of New Peptide Antibiotics, Cirratiomycin A and B
• The Structures of Diethylaminoethylated Glucose and Oligosaccharides Derived from Cationic Starch
• The Structure of Latosillan, a New Differentiation Inducer of Mouse Myeloid Leukemia Cells (M 1)
• Capoamycin, a New Isotetracenone Antibiotic
• Studies on the Biosynthesis of Fosfomycin. Conversion of 2-Hydroxyethylphosphonic Acid and 2-Aminoethylphosphonic Acid to Fosfomycin
• Anti-conidial Germination Factors Induced in the Presence of Probenazole in Infected Host Leaves. III. Structural Elucidation of Substances A and C
• Studies on Apple Canker Disease. The Necrotic Toxins Produced by Valsa ceratosperma
• Latosillan, a New Differentiation Inducer of Mouse Myeloid Leukemia Cells (Ml): Taxonomy, Fermentation, Isolation, Physicochemical Properties and Biological Properties
• Isolation of New Saponins from the Aerial Part of Bupleurum kunmingense Y. Li et S. L. Pan
• Kerriamycins A, B and C, New Isotetracenone Antibiotics
• Isolation of Triterpenoid Glycosides (Saikosaponins) from Bupleurum kunmingense and Their Chemical Structures

もっと見る 閉じる

スポンサーリンク