YM-216391, a Novel Cytotoxic Cyclic Peptide from Streptomyces nobilis : I. Fermentation, Isolation and Biological Activities
スポンサーリンク
概要
- 論文の詳細を見る
- 2005-01-25
著者
-
Suzuki K
Astellas Research Service Co. Ltd. Astellas Pharma Inc.
-
SOHDA Kin-ya
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
-
SUZUKI Ken-ichi
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
-
TANAKA Akihiro
Corporate Communications Department, Yamanouchi Pharmaceutical Co., Ltd.
-
NAGAI Koji
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
-
YAMORI Takao
Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Resea
-
Yamori Takao
Division Of Experimental Chemotherapy Cancer Chemotherapy Center Japanese Foundation For Cancer
-
Sohda Kin-ya
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
-
Sohda Kin-ya
Drug Metabolism Laboratories Drug Development Division Yamanouchi Pharmaceutical Co. Ltd.
-
Shin‐ya K
The University Of Tokyo
-
Nagai Koji
アステラス製薬
-
Nagai Koji
Microbiology Laboratories Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
-
Tanaka A
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
-
Suzuki Ken-ichi
Astellas Research Service Co. Ltd. Astellas Pharma Inc.
-
Tanaka Akihiro
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
-
Nagai Kazuo
Fermentation Research Laboratories Drug Discovery Research Astellas Pharma Inc.
-
Tanaka Akihiro
Corporate Communications Department Yamanouchi Pharmaceutical Co. Ltd.
-
Suzuki Ken-ichi
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
-
Yamori Takao
Division Of Molecular Pharmacology Cancer Chemotherapy Center Japanese Foundation For Cancer Researc
関連論文
- Discovery of Phosphatidylinositol 3-Kinase Inhibitory Compounds from the Screening Committee of Anticancer Drugs (SCADS) Library
- JBIR-26, a Novel Natural Compound from Streptomyces sp. AK-AH76, Regulates Mammalian Circadian Clock
- Burkholone, A New Cytotoxic Antibiotic against IGF-I Dependent Cells from Burkholderia sp.
- YM-216391, a Novel Cytotoxic Cyclic Peptide from Streptomyces nobilis : II. Physico-chemical Properties and Structure Elucidation
- YM-216391, a Novel Cytotoxic Cyclic Peptide from Streptomyces nobilis : I. Fermentation, Isolation and Biological Activities
- YM-92447 (Spinosulfate A), a Neuraminidase Inhibitor Produced by an Unidentified Pycnidial Fungus
- YM-193221, a Novel Antifungal Antibiotic Produced by Pseudallescheria ellipsoidea
- YM-215343, a Novel Antifungal Compound from Phoma sp. QN04621
- Oximidine III, a New Antitumor Antibiotic against Transformed Cells from Pseudomonas sp. II. Structure Elucidation
- Oximidine III, a New Antitumor Antibiotic against Transformed Cells from Pseudomonas sp. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activity
- Microbial Glycosylation and Acetylation of Brefeldin A
- YM-254890, a Novel Platelet Aggregation Inhibitor Produced by Chromobacterium sp.QS3666
- YM-266183 and YM-266184, Novel Thiopeptide Antibiotics Produced by Bacillus cereus Isolated from a Marine Sponge II. Structure Elucidation
- YM-266183 and YM-266184, Novel Thiopeptide Antibiotics Produced by Bacillus cereus Isolated from a Marine Sponge I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Properties
- YM-181741, a Novel Benz[a]anthraquinone Antibiotic with Anti-Helicobacter pylori Activity from Streptomyces sp.
- Neuroprotectins A and B, Bicyclohexapeptides Protecting Chick Telencephalic Neurons from Excitotoxicity : II. Structure Determination
- Quinolactacins A, B and C : Novel Quinolone Compounds from Penicillium sp. EPF-6 II. Physico-chemical Properties and Structure Elucidation
- Quinolactacins A, B and C : Novel Quinolone Compounds from Penicillium sp. EPF-6 I. Taxonomy, Production, Isolation and Biological Properties
- γ-Pyrone Compounds with Selective and Potent Anti-Helicobacter pylori Activity
- YM-170320, a Novel Lipopeptide Antibiotic Inducing Morphological Change of Colonies in a Mutant of Candida tropicalis pK233
- YM-47515, a Novel Isonitrile Antibiotic from Micromonospora echinospora subsp. echinospora
- New Members of the Trichothecene Family
- Diversity, Salt Requirement, and Antibiotic Production of Actinobacteria Isolated from Marine Sponges
- Pladienolides, New Substances from Culture of Streptomyces platensis Mer-11107 : III. In Vitro and In Vivo Antitumor Activities
- A Novel Indole-diterpenoid, JBIR-03 with Anti-MRSA Activity from Dichotomomyces cejpii var. cejpii NBRC 103559
- A Novel Nuclear Export Inhibitor JBIR-02, a New Piericidin Discovered from Streptomyces sp. ML55
- Selective Cytotoxic Activity of Valinomycin against HT-29 Human Colon Carcinoma Cells via Down-Regulation of GRP78(Pharmacology)
- Structure of Thioviridamide, a Novel Apoptosis Inducer from Streptomyces olivoviridis
- Thioviridamide, a Novel Apoptosis Inducer in Transformed Cells from Streptomyces olivoviridis
- Studies on Terpenoids Produced by Actinomycetes : Isolation and Structural Elucidation of Antioxidative Agents, Naphterpins B and C
- Deoxyverrucosidin, a Novel GRP78/BiP Down-regulator, Produced by Penicillium sp
- Prunustatin A, a Novel GRP78 Molecular Chaperone Down-regulator Isolated from Streptomyces violaceoniger
- Structure of Tyroscherin, an Antitumor Antibiotic against IGF-1-dependent Cells from Pseudallescheria sp
- Byssochlamysol, a New Antitumor Steroid against IGF-1-dependent Cells from Byssochlamys nivea II. Physico-chemical Properties and Structure Elucidation
- Byssochlamysol, a New Antitumor Steroid against IGF-1-dependent Cells from Byssochlamys nivea I, taxonomy, Fermentation, Isolation and Biological Activity
- Structure of Aspochalasin H, a New Member of the Aspochalasin Family
- A Novel Neuronal Cell Protecting Substance, Halxazone, Produced by Streptomyces halstedii
- Neuroprotectins A and B, Bicyclohexapeptides Protecting Chick Telencephalic Neuronal Cells from Excitotoxicity : I. Fermentation, Isolation, Physico-chemical Properties and Biological Activity
- Ammocidin, a New Apoptosis Inducer in Ras-dependent Cells from Saccharothrix sp. : II. Physico-chemical Properties and Structure Elucidation
- Ammocidin, a New Apoptosis Inducer in Ras-dependent Cells from Saccharothrix sp. : I. Production, Isolation and Biological Activity
- Selective Cytotoxicity and Stereochemistry of Aspochalasin D
- Phoenistatin, A New Gene Expression-Enhancing Substance Produced by Acremonium fusigerum
- Isolation of a Novel Gene Showing Reduced Expression in Metastatic Colorectal Carcinoma Cell Lines and Carcinomas
- A Novel Versipelostatin Analogue, Versipelostatin F Isolated from Streptomyces versipellis 4083-SVS6
- A Novel Antimycin-like Compound, JBIR-06, from Streptomyces sp. ML55
- Novel GRP78 Molecular Chaperone Expression Down-regulators JBIR-04 and -05 Isolated from Streptomyces violaceoniger
- New Aureothin Derivative, Alloaureothin, from Streptomyces sp. MM23
- Absolute Quantification of Four Isoforms of the Class I Phosphoinositide-3-kinase Catalytic Subunit by Real-Time RT-PCR(Communications to the Editor)
- Trapping Effect of Eugenol on Hydroxyl Radicals Induced by L-DOPA in Vitro
- Antioxidant Activity of Propofol and Related Monomeric and Dimeric Compounds
- Stawamycin Analog, JBIR-11 from Streptomyces viridochromogenes subsp. sulfomycini NBRC 13830
- Total Synthesis of Telomestatin
- Total Synthesis of Spiruchostatin A
- P-286 Total Synthesis of Spiruchostatin A
- P-255 TOTAL SYNTHESIS OF TELOMESTATIN
- Studies on the distribution of alkalophilic and alkali- tolerant soil fungi II : Fungal flora in two limestone caves in Japan
- Diheteropeptin, a Novel Substance with TGF-β-like Activity, Produced by a Fungus, Diheterospora chlamydosporia : II. Physico-chemical Properties and Structure Elucidation
- Diheteropeptin, a New Substance with TGF-β-like Activity, Produced by a Fungus, Diheterospora chlamydosporia : I. Production, Isolation and Biological Activities
- Identification of Candidate Genes Determining Chemosensitivity to Anti-cancer Drugs of Gastric Cancer Cell Lines
- Identification of candidate predictive markers of anticancer drug sensitivity using a panel of human cancer cell lines
- Molecular characterization of the flavonoid biosynthesis of Verbena hybrida and the functional analysis of verbena and Clitoria ternatea F3'5'H genes in transgenic verbena
- Application of LC-NMR for Characterization of Rat Urinary Metabolites of Zonampanel Monohydrate (YM872)
- Identification of JTP-70902, a p15^-inductive compound, as a novel MEK1/2 inhibitor
- ANTITUMOR EFFICACIES OF ACLACINOMYCIN A BY ORAL ADMINISTRATION
- YM-32890 A and B, New Types of Macrolide Antibiotis Produced by Cytophaga sp.
- YM-47522, a Novel Antifungal Antibiotic Produced by Bacillus sp-II. Structure and Relative Stereochemistry
- Establishment of a Hepatocyte Cell Line Producing Growth-promoting Factors for Liver-colonizing Tumor Cells
- Anticancer and Some Biological Activities of Thiazinotrienomycin B
- Preparation of Highly Potent and Selective Non-Peptide Antagonists of the Arginine Vasopressin V_ Receptor by Introduction of a 2-Ethyl-1H-1-imidazolyl Group
- Development and Characterization of a Model of Liver Metastasis Using Human Colon Cancer HCT-116 Cells(Highlighted paper selected by Editor-in-chief,Miscellaneous)
- Studies on New Antitumor Antibiotics, Leptofuranins A, B, C and D II. Physicochemical Properties and Structure Elucidation
- Studies on New Antitumor Antibiotics, Leptofuranins A, B, C and D I. Taxonomy, Fermentation, Isolation and Biological Activities
- Sesquiterpenoids and Flavonoids from the Aerial Parts of Tithonia diversifolia and Their Cytotoxic Activity
- Comparative Studies of a Humanized Anti-glycoprotein IIb/IIIa Monoclonal Antibody, YM337, and Abciximab on in Vitro Antiplatelet Effect and Binding Properties
- Studies on the distribution of alkalophilic and alkali-tolerant soil fungi I
- YM-47522, a Novel Antifungal Antibiotic Produced by Bacillus sp-I. Taxonomy, Fermentation, Isolation and Biological Properties
- Effect of Metacycloprodigiosin, an Inhibitor of Killer T Cells, on Murine Skin and Heart Transplants
- β-Hydroxyisovalerylshikonin Is a Novel and Potent Inhibitor of Protein Tyrosine Kinases
- Novel Malonamide Derivatives as α_vβ_3 Antagonists.Syntheses and Evaluation of 3-(3-Indolin-1-yl-3-oxopropanoyl)aminopropanoic Acids on Vitronectin Interaction with α_vβ_3
- Dereplication of Streptomyces Strains by Automated Southern Hybridization with a Polyketide Synthase Gene Probe
- YM-30059, a Novel Quinolone Antibiotic Produced by Arthrobacter sp.
- Kalimantacins A, Band C, Novel Antibiotics from Alcaligenes sp. YL-02632S I. Taxonomy, Fermentation, Isolation and Biological Properties
- Motif-programmed artificial protein induces apoptosis in several cancer cells by disrupting mitochondria
- JBIR-66, a New Metabolite Isolated from Tunicate-Derived Saccharopolyspora sp. SS081219JE-28
- JBIR-37 and -38, Novel Glycosyl Benzenediols, Isolated from the Sponge-Derived Fungus, Acremonium sp. SpF080624G1f01
- JBIR-15, a New Aspochracin Derivative, Isolated from a Sponge-Derived Fungus, Aspergillus sclerotiorum Huber Sp080903f04
- Total Synthesis of Largazole and Its Biological Evaluation
- Anti-tumor Efficacy of Paclitaxel against Human Lung Cancer Xenografts
- Stereoselective Synthesis of Methyl (Z)-(4,4-Difluoro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene) acetate Using a Dianion Horner-Wadsworth-Emmons Reagent
- Preparation of Non-peptide, Highly Potent and Selective Antagonists of Arginine Vasopressin V_ Receptor by Introduction of Alkoxy Groups
- Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites
- Anguinomycins C and D, New Antitumor Antibiotics with Selective Cytotoxicity against Transformed Cells
- Selective Cytotoxicity of Mycophenolic Acid against Transformed Cells
- Phosphatidylinositol 3-kinase inhibitors : promising drug candidates for cancer therapy
- Effect of ZSTK474, a Novel Phosphatidylinositol 3-Kinase Inhibitor, on DNA-Dependent Protein Kinase(Pharmacology)
- Effectiveness of combined treatment using X-rays and a phosphoinositide 3-kinase inhibitor, ZSTK474, on proliferation of HeLa cells in vitro and in vivo
- ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms
- Potentiation of Bleomycin in Jurkat Cells by Fungal Pycnidione
- Development of an Immunohistochemical Protein Quantification System in Conjunction with Tissue Microarray Technology for Identifying Predictive Biomarkers for Phosphatidylinositol 3-Kinase Inhibitors
- Search for Novel Anti-tumor Agents from Ridaifens Using JFCR39, a Panel of Human Cancer Cell Lines