Stereoselective Synthesis of Methyl (Z)-(4,4-Difluoro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene) acetate Using a Dianion Horner-Wadsworth-Emmons Reagent

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概要

• 論文の詳細を見る

• Stereoselective synthesis of methyl (Z)-(4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene) acetate (1a) is described. Z-selectivity of the Horner-Wadsworth-Emmons (HWE) reaction was obtained based on an investigation of the reaction conditions for introduction of a methylidene group onto the 5-position of benzazepine.

• 公益社団法人日本薬学会の論文
• 2005-05-01

著者

• TANAKA Akihiro

  Corporate Communications Department, Yamanouchi Pharmaceutical Co., Ltd.

• Tanaka A

  Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• Tanaka A

  Yamanouchi U.k. Ltd. Surrey Gbr

• 増田 明

  富山医科薬科大学麻酔科

• Kawano Noriyuki

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.

• SHIMADA Yoshiaki

  Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.

• AKANE Hiroaki

  Clinical Development Department, Yamanouchi Pharmaceutical Co., Ltd.

• TANIGUCHI Nobuaki

  Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.

• MATSUHISA Akira

  Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.

• Akane Hiroaki

  Clinical Development Department Yamanouchi Pharmaceutical Co. Ltd.

• Matsuhisa Akira

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.

• Matsuhisa Akira

  Gastrointestinal Research Laboratories Institute For Drug Discovery Research Yamanouchi Pharmaceutic

• Taniguchi Nobuaki

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.

• Shimada Yoshiaki

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.

• Tanaka Akihiro

  Corporate Communications Department Yamanouchi Pharmaceutical Co. Ltd.

• Tahara Atsuo

  Drug Discovery Research Astellas Pharma Inc.

• Matsuhisa Akira

  Institute For Drug Discovery Research Astellas Pharma Inc.

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