Cytotoxic Activity toward KB Cells of 2-Substituted Naphtho[2,3-b]furan-4,9-diones and Their Related Compounds

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概要

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• We investigated the cytotoxic activity of 2-substituted naphtho[2,3-b]furan-4,9-diones. We have previously synthesized 33 types of 2-substituted and related compounds, and the cytotoxic activity of these compounds was then examined by a KB cell culture assay. 2-(3-Furanoyl)benzoic acids and 1,4-naphthoquinones had no activity. 2-Acetyl-4,9-dimethoxynaphtho[2,3-b]furan 4 showed low activity. However, parent naphtho[2,3-b]furan-4,9-dione 2 and most 2-substituted derivatives exhibited cytotoxic activity. The parent structure was therefore for cytotoxicity. 2-Formylnaphtho[2,3-b]furan-4,9-dione 11 had particularly potent activity (ED50=0.09 μg/ml).

• 2006-04-23

著者

• Tanaka A

  Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• TANAKA Akira

  Faculty of Agriculture, Hokkaido University

• TSUDA Tadashi

  Faculty of Pharmaceutical Sciences Josai University

• Yamamoto K

  Faculty Of Pharmaceutical Sciences Josai University

• OGAWA Masayuki

  Faculty of Pharmaceutical Sciences, Josai University

• KOYANAGI Jyunichi

  Faculty of Pharmaceutical Sciences, Josai University

• SUGAYA Aiko

  Faculty of Pharmaceutical Sciences, Josai University

• OHGUCHI Hiromi

  Faculty of Pharmaceutical Sciences, Josai University

• NAKAYAMA Kouji

  Faculty of Pharmaceutical Sciences, Josai University

• YAMAMOTO Katsumi

  Faculty of Pharmaceutical Sciences, Josai University

• Sugaya Aiko

  Faculty Of Pharmaceutical Sciences Josai University

• Nakayama K

  Faculty Of Pharmaceutical Sciences Josai University

• Koyanagi J

  Faculty Of Pharmaceutical Sciences Josai University

• Koyanagi Jyunichi

  Faculty Of Pharmaceutical Sciences Josai International University

• Ohguchi Hiromi

  Faculty Of Pharmaceutical Sciences Josai University

• Ogawa Masayuki

  Faculty Of Pharmaceutical Sciences Josai University

• Tanaka Akira

  Faculty Of Agriculture Hokkaido University

• Yamamoto Katsumi

  Faculty Of Pharmaceutical Sciences Josai University

• SUGAYA AIKO

  Faculty of Pharmaceutical Science, Toho University

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