In Vitro Stability and in Vivo Absorption Studies of Colloidal Particles Formed from a Solid Dispersion System

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概要

• 論文の詳細を見る

• We investigated the physicochemical and pharmaceutical properties of a solid dispersion (SD) derived from a solution of the poorly water-soluble drug (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), hydroxypropylmethylcellulose 2910 (TC-5E) and polyoxyethylene hydrogenated caster oil 60 (HCO-60). Colloidal particles produced when the SD was dispersed into water had a mean diameter of 160 nm and contained 67-77% YM022. Powder X-ray diffractometr showed that YM022 existed in the colloidal particles in an amorphous state. The particle diameter and YM022 content remained unchanged during storage for 7 d, confirming that the colloidal solution was stable. On oral administration to rats, good absorption was observed for both the colloidal solution prepared immediately before and the sample stored for 7 d before administration. Thus, the stability of this colloidal solution of SD was confirmed by in vitro storage tests and by in vivo absorption experiments in rats.

• 公益社団法人日本薬学会の論文
• 1996-12-15

著者

• YAMAMOTO Keiji

  Faculty of Pharmaceutical Sciences, Chiba University

• Yamazaki S

  Novel Pharma Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• Yamamoto K

  Faculty Of Pharmaceutical Sciences Josai University

• YANO Katsuhiko

  Novel Pharma Laboratories Yamanouchi Pharmaceutical Co., Ltd.,

• KAJIYAMA Atsushi

  Novel Pharma Laboratories Yamanouchi Pharmaceutical Co., Ltd.,

• YAMAZAKI Shigeru

  Novel Pharma Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.,

• MATSUMURA Yoshisuke

  Novel Pharma Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.,

• WATANABE Kouji

  Safety Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.,

• Yano K

  Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.

• Kajiyama A

  Novel Pharma Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• Matsumura Yoshisuke

  Novel Pharma Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• Yamamoto Keiji

  Faculty Of Pharmaceutical Sciences Chiba University

• Watanabe Kouji

  Safety Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• Watanabe Kouji

  Safety Research Laboratories Development Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• Yamamoto Keiji

  Faculty Of Materials Science And Engineering Science University Of Tokyo In Yamaguchi

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