The Diverse Effects of a Chinese Medicine, Qing Nao Yi Zhi Fang, on the Proliferation of Human Arterial Smooth Muscle Cells and Endothelial Cells(Pharmacology)
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概要
- 論文の詳細を見る
Qing Nao Yi Zhi Fang (QNYZ), a Chinese medicine, has been developed as a drug for the prevention and treatment of vascular dementia. We examined the effects of QNYZ-treated serum and QNYZ on the proliferation of human arterial smooth muscle cells (SMCs) and endothelial cells (ECs). SMCs did not grow in a medium containing 10% QNYZ serum. QNYZ also completely inhibited the proliferation of SMCs at higher concentrations (500-1000μg/ml), although no detectable inhibitory activity on the SMC proliferation was observed at lower concentrations (100-200μg/ml). In contrast, QNYZ (250-500μg/ml) significantly stimulated the proliferation of ECs and prostacyclin production in ECs. These results suggest that QNYZ may have suppressive effects on the development of intimal thickening in atherosclerosis and after arterial wall injury.
- 公益社団法人日本薬学会の論文
- 2004-07-01
著者
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AOYAGI Masaru
Department of Otolaryngology, Yamagata University School of Medicine
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Aoyagi M
Department Of Neurosurgery Tokyo Medical And Dental University
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Yamamoto N
Central Research Laboratories Kaken Pharmaceutical Co. Ltd.
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Aoyagi Masaru
Department Of Neurosurgery Graduate School Tokyo Medical And Dental University
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Aoyagi Masaru
Nanoarchitechtonics Research Center National Institute Of Advanced Industrial Science And Technology
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Yamamoto Kiyotaka
Department of Cell Biology, Tokyo Metropolitan Institute of Gerontology
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ZHANG Junping
Department of Cell Biology, Tokyo Metropolitan Institute of Gerontology
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YAMAMOTO Mari
Department of Cell Biology, Tokyo Metropolitan Institute of Gerontology
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YAMAMOTO Naofumi
Department of Neurosurgery, Tokyo Medical and Dental University
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KANAI Misaki
Department of Cell Biology, Tokyo Metropolitan Institute of Gerontology
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ZHANG Boli
Department of Pharmacology, Tianjin University of Traditional Chinese Medicine
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Zhang Boli
Department Of Pharmacology Tianjin University Of Traditional Chinese Medicine
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Kanai Misaki
Department Of Cell Biology Tokyo Metropolitan Institute Of Gerontology
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Zhang J
Department Of Cell Biology Tokyo Metropolitan Institute Of Gerontology:department Of Pharmacology Ti
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Aoyagi Masaru
The Graduation University For Advanced Studies
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Yamamoto Naofumi
Department Of Neurosurgery Tokyo Medical And Dental University
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Yamamoto K
Faculty Of Pharmaceutical Sciences Josai University
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Zhang Junping
Department Of Cell Biology Tokyo Metropolitan Institute Of Gerontology:department Of Pharmacology Ti
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Yamamoto Kiyotaka
Department Of Cell Biology Tokyo Metropolitan Institute Of Gerontology
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Yamamoto M
Department Of Cell Biology Tokyo Metropolitan Institute Of Gerontology
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Yamamoto Mari
Department Of Cell Biology Tokyo Metropolitan Institute Of Gerontology
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Zhang Junping
Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University
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