Clofibric Acid Increases the Formation of Oleic Acid in Endoplasmic Reticulum of the Liver of Rats
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概要
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The effects of 2-(4-chlorophenoxy)-2-methylpropionic acid (clofibric acid) on the formation of oleic acid (18:1) from stearic acid (18:0) and utilization of the 18:1 formed for phosphatidylcholine (PC) formation in endoplasmic reticulum in the liver of rats were studied in vivo. [14C]18:0 was intravenously injected into control Wistar male rats and rats that had been fed on a diet containing 0.5% (w/w) clofibric acid for 7 days; and the distribution of radiolabeled fatty acids among subcellular organelles, microsomes, peroxisomes, and mitochondria, was estimated on the basis of correction utilizing the yields from homogenates of marker enzymes for these organelles. The radioactivity was mostly localized in microsomes and the radiolabeled fatty acids present in microsomes were significantly increased by the treatment of rats with clofibric acid. The formation of radiolabeled 18:1 in microsomes markedly increased and incorporations of the formed [14C]18:1 into PC and phosphatidylethanolamine in microsomes were augmented in response to clofibric acid. The [14C]18:1 incorporated into PC was mostly located at the C-2 position, but not the C-1 position, of PC, and the radioactivity in 18:1 at the C-2 position of PC was strikingly increased by clofibric acid. These results obtained from the in vivo experiments directly link the findings that clofibric acid treatment induces microsomal stearoyl-CoA desaturase and 1-acylglycerophosphocholine acyltransferase in the liver and the findings that the treatment with the drug elevated absolute mass and mass proportion of 18:1 at the C-2 position, but not the C-1 position, of PC in the liver together.
- 社団法人 日本薬理学会の論文
著者
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Hirose Akihiko
National Inst. Of Health Sciences
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Hirose Akihiko
Division Of Risk Assessment Biological Safety Research Center National Institute Of Health Sciences
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Hirose Akihiko
Division Of Risk Assessment National Institute Of Health Sciences
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SAKAMOTO Takeshi
Faculty of Pharmaceutical Sciences, Josai University
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KAWASHIMA Yoichi
Faculty of Pharmaceutical Sciences, Josai University
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TSUDA Tadashi
Faculty of Pharmaceutical Sciences Josai University
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Sunaga Katsuyoshi
Faculty Of Phamaceutical Sciences Josai University
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Hirose Akihiko
Division Of Toxicology National Institute Of Health Sciences
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Kudo Naomi
Faculty Of Pharmaceutical Science Josai University
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Yamazaki Tohru
Faculty Of Enginering Himeji Institute Of Technology
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Hirose Akihiko
National Inst. Of Health Sciences (nihs)
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Mitsumoto Atsushi
Faculty Of Pharmaceutical Sciences Josai International University
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Sakamoto Takeshi
Faculty Of Pharmaceutical Sciences Josai University
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Kawashima Yoichi
Faculty Of Pharmaceutical Science Josai University
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