EFFECT OF CLOFIBRIC ACID ADMINISTRATION ON PALMITOYLCoA HYDROLASE ACTIVITY IN RAT LIVER
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概要
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The activity of palmitoyl-CoA hydrolase (EC 3. 1. 2. 2.) in the liver from clofibric acid (p-chlorophenoxyisobutyric acid)-treated rats was studied. The study for subcellular localization showed that palmitoyl-CoA hydrolase was found in both cytosolic and microsomal fractions. Feeding of diet containing 0.5% clofibric acid for 6 days, the specific activities of palmitoyl-CoA hydrolase in homogenates, microsomes and cytosol were increased 5,2 and 22 times, respectively, compared with that in control rats. Gel filtration of cytosolic fraction showed two new peaks, which have the activity capable of hydrolyzing palmitoyl-CoA and different molecular weights compared with the peaks in cytosol of control rat liver. Acyl-CoA hydrolases in cytosolic fraction showed different kinetic properties with each other.
- 公益社団法人日本薬学会の論文
著者
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KOZUKA HIROSHI
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Kozuka Hiroshi
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Kozuka Hiroshi
Faculty Of Medical Sciences Toyama Medical And Pharmaceutical University
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Katoh Haruyo
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Kawashima Yoichi
Faculty Of Pharmaceutical Sciences Josai University
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Kawashima Yoichi
Faculty Of Pharmaceutical Science Josai University
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KAWASHIMA YOICHI
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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