The Effect of Zinc on the Metabolism of Embryonic Chicken Bone in Tissue Culture and Zinc-Cadmium Interaction
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概要
- 論文の詳細を見る
In order to investigate the effects of zinc on the contents of collagen and mineral in bone, femurs obtained from 9-day-old chick embryo were cultivated for 6 days in the presence of 58,139 or 580μM ZnCl_2. Decreases in the contents of mineral and collagen were caused by zinc concentrations of 193μM and above. Zinc inhibited incorporation of ^<45>Ca into bone. Release of ^<45>Ca from bone was slightly inhibited by zinc. Zinc was shown to have an inhibitory effect on bone formation rather than on bone resorption. On the other hand, 27,54 or 108μM zinc prevented a decrease in collagen content caused by cadmium, though zinc did not prevent a decrease in mineral content caused by cadmium. Cytosol obtained from zinc-treated bones was found to contain metallothionein-like protein, which might participate in zinc-induced tolerance to cadmium toxicity. These results indicate that the coexistence ef zinc at low concentrations with cadminm lowered bone mineral content but did not affect the matrix.
- 公益社団法人日本薬学会の論文
- 1983-06-30
著者
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Kaji Toshiyuki
Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmaceutical University
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MIYAHARA Tatsuro
Faculty of Medicine, University of Toyama
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Miyahara T
Univ. Shizuoka Shizuoka Jpn
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Miyahara Tatsuro
Faculty Of Medicine University Of Toyama
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Kaji Toshiyuki
Faculty Of Pharmaceutical Sciences Hokuriku University
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KOZUKA HIROSHI
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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SHIRAKAWA ECHIKO
Faculty of Pharmaceutical Sciences
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KATO TERUTAKA
Faculty of Medical Sciences, Toyama Medical and Pharmaceutical University
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Kato Terutaka
Faculty Of Medical Sciences Toyama Medical And Pharmaceutical University
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Kozuka H
Hiroshima Bunkyo Women's College
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Kozuka Hiroshi
Faculty Of Medical Sciences Toyama Medical And Pharmaceutical University
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Matsuhashi T
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Kawajiri Tadashi
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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