The Cytotoxicity of Methylmercury in Human Microvascular Endothelial Cells and Pericytes in Culture
スポンサーリンク
概要
- 論文の詳細を見る
Methylmercury is an environmental neurotoxin that induces severe neurological damage in the brain of humans and animals. The main pathological characteristic of methylmercury neurotoxicity is the location of the damage; lesions are localized around the deep sulci and fissures in the cerebral cortex, such as the calcarine fissure, and the granule cell layer of the cerebellum. Since the localization of the damage is suggested to be a result of secondary damage occurring due to edematous change in the white cortex, the toxicity of methylmercury to cells that compose the microvessels―endothelial cells and pericytes―may be important for understanding the neurotoxicity of methylmercury. We investigated the toxicity of methylmercury to human brain microvascular endothelial cells and pericytes using a cell culture system. It was revealed that the toxicity of methylmercury to microvascular cells depends on the cell type and density. It is suggested that vascular tissue is one of the targets of methylmercury toxicity and that this may contribute to the progression of edematous change in the brain. Methylmercury may also be involved in the progression of cardiovascular diseases.
- 公益社団法人 日本薬学会の論文
著者
-
Kaji Toshiyuki
Faculty Of Pharmaceutical Sciences Hokuriku University
-
Kaji Toshiyuki
Faculty of Pharmaceutical Sciences, Tokyo University of Science
-
Hirooka Takashi
Faculty of Pharmaceutical Sciences, Tokyo University of Science
関連論文
- Induction of versican V0 variant synthesis by activation of protease-activated receptor-1 in vascular smooth muscle cells
- Induction of Decorin Core Protein Synthesis by Advanced Glycation Endproducts in Cultured Vascular Smooth Muscle Cells(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Remodeling of Vascular Endothelial Glycocalyx by Basic Fibroblast Growth Factor (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- Mechanism of Cadmium-Copper Interaction in Embryonic Chick Bone in Tissue Culture (Proceedings of the 12 th Symposium on Environmental Pollutants and Toxicology) (Regular Presentations)
- Effect of Luobuma leaves against oxidation of low-density lipoprotein : a cell culture assay
- Regulation of proteoglycan synthesis by basic fibroblast growth factor in cultured vascular smooth muscle cells
- The Effects of Cadmium on a Clonal Osteogenetic Cell, MC 3T3-El
- Interaction between Cadmium and Copper in Relation to the Collagen Metabolism of Embryonic Chick Bone in Tissue Culture (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology)
- The Effect of Zinc on the Metabolism of Embryonic Chicken Bone in Tissue Culture and Zinc-Cadmium Interaction
- Effect of Lead on the Proliferation of Cultured Vascular Endothelial Cells and Vascular Smooth-Muscle Cells (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Effects of Cadmium on the Regulation of Blood Fibrinolysis by Vascular Endothelial Cells, Vascular Smooth-Muscle Cells and Fibroblasts (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- The Cytotoxicity of Methylmercury in Human Microvascular Endothelial Cells and Pericytes in Culture