Studies on the Metabolism and Toxicity of Dinitrotoluenes : Metabolism of Dinitrotoluenes by Rhodotorula glutinis and Rat Liver Homogenate
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概要
- 論文の詳細を見る
The formation ratios of reduction metabolites formed by R. glutinis and rat liver homogenate from 2,3-, 2,4-, 3,4- and 2,5-dinitrotoluene (DNT) were investigated. The reduction metabolites formed by both systems consisted of two kinds of monoaminonitrotoluenes and hydroxylaminonitrotoluenes from each substrate. The relation of major and minor products in the microbial system paralleled that in the mammalian system in vitro. The usefulness of the microbial system for metabolic and toxicological studies of DNTs is discussed. In addition, the formation ratios of the two monoamino compounds formed by both species were consistent with theoretical reactivity indices calculated by the molecular orbital method, suggesting that quantum chemical methods may be applicable to studies of the enzymatic reduction reactivities of DNTs.
- 公益社団法人日本薬学会の論文
- 1978-10-31
著者
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Mori Yoshihiro
Faculty Of Pharmaceutical Sciences Toyama Medical Pharmaceutical University
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MIYAHARA Tatsuro
Faculty of Medicine, University of Toyama
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Miyahara T
Univ. Shizuoka Shizuoka Jpn
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Miyahara Tatsuro
Faculty Of Medicine University Of Toyama
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KOZUKA HIROSHI
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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MORI MASAAKI
Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University
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Mori Masaaki
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Kozuka H
Hiroshima Bunkyo Women's College
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KATAYAMA KATSUHISA
Faculty of Pharmaceutical Sciences, Toyama Medical Pharmaceutical University
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MATSUHASHI TATSUO
Faculty of Pharmaceutical Sciences, Toyama Medical Pharmaceutical University
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NAGAHARA SHIGERU
Faculty of Pharmaceutical Sciences, Toyama Medical Pharmaceutical University
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Kozuka Hiroshi
Faculty Of Medical Sciences Toyama Medical And Pharmaceutical University
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Matsuhashi Tatsuo
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Matsuhashi T
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Katayama Katsuhisa
Faculty Of Pharmaceutical Sciences Toyama Medical Pharmaceutical University
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Nagahara Shigeru
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Nagahara Shigeru
Faculty Of Pharmaceutical Sciences Toyama Medical Pharmaceutical University
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