STUDY ON HYDROXAMIC ACIDS AND THEIR UREASE INHIBITORY POTENCY BY QUANTUM CHEMISTRY CALCULATION

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概要

• 論文の詳細を見る

• The electronic structures of 34 hydroxamic acids [R-(CONHCH_2)_n-CONHOH, R=aromatic or aliphatic, n=1 or 0] were calculated by the INDO method and their urease inhibitory potencies were discussed in terms of the calculated electronic parameters and molar refraction. The charge distribution of-CONHOH residue which has been expected as a functional group for inhibition slightly be affected by the change of R-moiety and by the presence or absence of the-CONHCH_2-residue. The best improved regression equation indicated that the inhibitory potency of hydroxamic acids was parabolically varied with the molar refraction and that the increase of the inhibitory potency by the presence of-CONHCH_2-residue was explained by the variation of the charge density of a carbon atom directlv bonding the-CONHOH group.

• 公益社団法人日本薬学会の論文

著者

• Kobashi Kyoichi

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• SHINODA Hiroyuki

  Faculty of Pharmaceutical Sciences, University of Toyama

• NAGAHARA SHIGERU

  Faculty of Pharmaceutical Sciences, Toyama Medical Pharmaceutical University

• HASE JUNICHI

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• Hase Junichi

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• KANODA MASAMI

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• Kanoda Masami

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Kobashi Kyoichi

  Faculty Of Phamaceutical Sciences Toyama Medical And Pharmaceutical University:fuji Chemical Industr

• Shinoda Hiroyuki

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Nagahara Shigeru

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Shinoda Hiroyuki

  Faculty of Pharmaceutical Science, Toyama Medical and Pharmaceutical University

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