Induction of Triglyceride Accumulation in the Liver of Rats by Perfluorinated Fatty Acids with Different Carbon Chain Lengths : Comparison with Induction of Peroxisomal β-Oxidation(Toxicology)
スポンサーリンク
概要
- 論文の詳細を見る
The potency to accumulate triglyceride (TG) was compared between perfluorinated fatty acids (PFCAs) with different carbon chain lengths in the liver of male and female rats and induction of peroxisomal β-oxidation. In male rats, either perfluoroheptanoic acid (C7) or perfluorooctanoic acid (C8) had no effect, although perfluorononanonic acid (C9) and perfluorodecanoic acid (C10) markedly accumulated TG. In female rats, C7, C8, and C9 did not cause TG accumulation, whereas C10 caused TG accumulation at the same level as in male rats. TG accumulation induced by C9 was regulated by the level of testosterone in male rats. In contrast with TG accumulation, peroxisomal β-oxidation was induced by C8, C9, and C10 in male rats and by C9 and C10 in female rats. Only a slight difference was observed in the induction by C9 between male and female rats. The induction of TG accumulation by these PFCAs occurred in a dose-dependent manner and significantly correlated with hepatic concentrations of PFCA regardless of their carbon chain length, as was observed with induction of peroxisomal β-oxidation. There is, however, a striking difference in the hepatic concentration of PFCA required to cause induction of TG accumulation and that of peroxisomal β-oxidation. The concentration of PFCA required to induce TG accumulation is much higher than that to induce peroxisomal β-oxidation. These results strongly suggest that TG accumulation induced by PFCAs, as well as the induction of peroxisomal β-oxidation, is dependent only on the number of PFCA molecules in hepatocytes, but is not due to the difference in their chemical structures, and that there is a marked difference in the PFCA threshold to cause distinct biological effects.
- 公益社団法人日本薬学会の論文
- 2003-01-01
著者
-
KAWASHIMA Yoichi
Faculty of Pharmaceutical Sciences, Josai University
-
Kudo Naomi
Faculty Of Pharmaceutical Sciences Josai University
-
Kudo Naomi
Faculty Of Pharmaceutical Science Josai University
-
Kawashima Yoichi
Faculty Of Pharmaceutical Science Josai University
関連論文
- Peroxisome Proliferators Attenuate Free Arachidonic Acid Pool in the Kidney Through Inducing Lysophospholipid Acyltransferases
- Effects of Supplemented Diacylglycerol Rich in Docosahexaenoic Acid on Serum Triacylglycerol in a Diet-Induced Hyperlipidemic Model of Rats Are Essentially Equivalent to Those of Triacylglycerol Rich in Docosahexaenoic Acid(Miscellaneous)
- The Effect of Cadmium on Arachidonate Release in Rabbit Alveolar Macrophages (Proceedings of the 14th Symposium on Environmental Pollutants and Toxicology)
- Rat Organic Anion Transporter 3 and Organic Anion Transporting Polypeptide 1 Mediate Perfluorooctanoic Acid Transport
- P8-46 Studies on mechanism of renal transport of perfluorooctanoic acid in rats(BLOOD/TOXICOKINETICS/OTHERS-2)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Sex hormone-regulated renal transport of perfluorooctanoic acid (KIDNEYS AND URINARY EXCRETION SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Sex Hormone Regulation of Rat Organic Anion Transporter 3 (rOAT3) Expression in Rat Kidney
- Effects of Several Heavy Metals on the Metabolism of Arachidonic Acid in Rabbit Alveolar Macrophages (Proceedings of the 18th Symposium on Toxicology, and Environmental Health)
- Modification of Carbon Tetrachloride-Induced Hepatotoxicity by Clofibric Acid in Rats
- Protection by Zinc against Cadmium Toxicity in Rat Liver and Kidney (Regular Presentations) (Proceedings of the 11 th Symposium on Environmental Pollutants and Toxicology)
- Effects of Dehydroepiandrosterone on Oleic Acid Formation in the Liver of Rats, Mice and Guinea Pigs
- Responses of the Liver to Perfluorinated Fatty Acids with Different Carbon Chain Length in Male and Female Mice : In Relation to Induction of Hepatomegaly, Peroxisomal β-Oxidation and Microsomal 1-Acylglycerophosphocholine Acyltransferase(Miscellaneous)
- TOXICITY AND TOXICOKINETICS OF PERFLUOROOCTANOIC ACID IN HUMANS AND ANIMALS
- Effects of Chronic Administration of Perfluorooctanoic Acid on Fatty Acid Metabolism in Rat Liver : Relationship among Stearoyl-Coenzyme A Desaturase, 1-Acylglycerophosphocholine Acyltransferase, and Acyl Composition of Microsomal Phosphatidylcholine
- EFFECTS OF SOME HYPOLIPIDEMIC DRUGS AND PHTHALIC ACID ESTERS ON FATTY ACID BINDING PROTEIN IN RAT LIVER
- Tissue Distribution and Hepatic Subcellular Distribution of Perfluorooctanoic Acid at Low Dose Are Different from Those at High Dose in Rats(Miscellaneous)
- Effects of Pioglitazone on Stearoyl-CoA Desaturase in Obese Zucker fa/fa Rats
- Stearoyl-CoA Desaturase Activity Is Elevated by the Suppression of Its Degradation by Clofibric Acid in the Liver of Rats
- Reducing Effect of Matrix Metalloproteinase Inhibitors on Serum Triacylglycerol in Streptozotocin-Induced Diabetic Rats and Zucker fa/fa Rats(Pharmacology)
- Effects of 8-2 Fluorotelomer Alcohol on Oleic Acid Formation in the Liver of Rats(Miscellaneous)
- Effects of Perfluorinated Fatty Acids with Different Carbon Chain Length on Fatty Acid Profiles of Hepatic Lipids in Mice
- Efficacy of urine bile acid as a non-invasive indicator of liver damage in rats
- Manifestation of psychiatric behaviors in a mouse model of griseofulvin-induced hepatic porphyria
- Clofibric Acid Increases the Formation of Oleic Acid in Endoplasmic Reticulum of the Liver of Rats
- Induction of Triglyceride Accumulation in the Liver of Rats by Perfluorinated Fatty Acids with Different Carbon Chain Lengths : Comparison with Induction of Peroxisomal β-Oxidation(Toxicology)
- Role of Stearoyl-CoA Desaturase in the Modification of Acyl Composition of Hepatic Phosphatidylcholine by Peroxisome Proliferators
- Effects of Cadmium on the Metabolism of Fatty Acid in Rat Liver (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- The Role of Zinc in Fatty Acid Metabolism in Rat Liver : Effects of Zinc Deficiency and Cadmium Administration (Regular Presentations) (Proceedings of the 15 th Symposium on Environmental Pollutants and Toxicology)
- The Effect of Cadmium-Microsome High-Molecular-Weight Protein Complex on Some Enzyme Activity (Proceedings of the 12 th Symposium on Environmental Pollutants and Toxicology) (Regular Presentations)
- Effects of 2,4-D and 2,4,5-T on Fatty Acid Metabolism in Rat Liver (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology)
- Difference in Hepatic Accumulation of Perfluorocarboxylic Acids with Different Carbon Chain Length in Rats(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Determination of perfluorinated carboxylic acids in biological samples by high-performance liquid chromatography
- EFFECT OF CLOFIBRIC ACID ADMINISTRATION ON PALMITOYLCoA HYDROLASE ACTIVITY IN RAT LIVER
- Effects of Perfluorooctanoic Acid on the Synthesis of Phospholipids in the Liver of Mice Fed a Dietary Soybean Oil, Perilla Oil or Fish Oil
- The Induction of Fatty Liver by Administration of Perfluorocarboxylic Acids in Rats (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- Fish Oil-Feeding Prevents Perfluorooctanoic Acid-Induced Fatty Liver in Mice (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)
- Clofibric Acid Increases the Formation of Oleic Acid in Endoplasmic Reticulum of the Liver of Rats
- Characterization of Fatty Acid Profile in the Liver of SHR/NDmcr-cp (cp/cp) Rats, a Model of the Metabolic Syndrome
- Induction of 1-Acylglycerophosphocholine Acyltransferase Genes by Fibrates in the Liver of Rats
- Effects of Fish Oil Feeding Alone in Combination with Clofibric Acid on Serum Levels of Triacylglycerol and Cholesterol in Rats
- Differential Induction of Stearoyl-CoA Desaturase 1 and 2 Genes by Fibrates in the Liver of Rats
- Behavioral and biochemical characterization of rats treated chronically with thioacetamide : proposal of an animal model for hepatic encephalopathy associated with cirrhosis
- Fibrates Reduce Triacylglycerol Content by Upregulating Adipose Triglyceride Lipase in the Liver of Rats
- A Simple and Sensitive Method for the Determination of Fibric Acids in the Liver by Liquid Chromatography
- Alterations by Clofibric Acid of Metabolism of Phosphatidylethanolamine in Rat-Liver