Peroxisome Proliferators Attenuate Free Arachidonic Acid Pool in the Kidney Through Inducing Lysophospholipid Acyltransferases
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概要
- 論文の詳細を見る
Attenuating effects of peroxisome proliferators on the concentration of free arachidonic acid by inducing 1-acyl-2-lysophospholipid acyltransferases in the kidney were studied. The administration of the three structurally dissimilar peroxisome proliferators, 2-(4-chlorophenoxy)-2-methylpropionic acid (clofibric acid), di(2-ethylhexyl)phthalate, and 2,2-(decamethylenedithio)diethanol, to rats or mice considerably increased the activities of microsomal 1-acylglycerophosphoethanolamine acyltransferase (LPEAT), 1-acylglycerophosphoinositol acyltransferase (LPIAT), 1-acylglycerophosphoserine acyltransferase (LPSAT), and 1-acylglycerophosphocholine acyltransferase (LPCAT), and the mRNA level of LPCAT3, but not the mRNA level of LPCAT1, LPCAT4, or LPEAT1, in the kidney and the liver. The proportions of arachidonic acid in phospholipids in renal microsomes are rather high for the low proportion of arachidonic acid in free fatty acids in renal microsomes of control rats. The treatment of rats with clofibric acid attenuated the concentration and the proportion of free arachidonic acid to about a half; nevertheless the treatment lowered slightly the proportions of arachidonic acid in phospholipids other than phosphatidylcholine. These results indicate that peroxisome proliferators upregulate the four 1-acyl-2-lysophospholipid acyltransferases of the kidney and, and the induced 1-acyl-2-lysophospholipid acyltransferases seem to play a physiologically crucial contribution in attenuating the pool of free arachidonic acid in the kidney.
- 社団法人 日本薬理学会の論文
- 2009-10-20
著者
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Hirose Akihiko
Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Science
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Hirose Akihiko
National Inst. Of Health Sciences
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Hirose Akihiko
Division Of Risk Assessment Biological Safety Research Center National Institute Of Health Sciences
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Hirose Akihiko
Division Of Risk Assessment National Institute Of Health Sciences
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YAMAZAKI Tohru
Faculty of Pharmaceutical Sciences, Josai University
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SAKAMOTO Takeshi
Faculty of Pharmaceutical Sciences, Josai University
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OKAZAKI Mari
Faculty of Pharmaceutical Sciences, Josai University
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MITSUMOTO Atsushi
Faculty of Pharmaceutical Sciences, Josai International University
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KUDO Naomi
Faculty of Pharmaceutical Sciences, Josai University
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KAWASHIMA Yoichi
Faculty of Pharmaceutical Sciences, Josai University
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Okazaki M
Faculty Of Pharmaceutical Sciences Josai University
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Hirose Akihiko
Division Of Toxicology National Institute Of Health Sciences
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Kudo N
Faculty Of Pharmaceutical Sciences Josai University
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Kudo Naomi
Faculty Of Pharmaceutical Science Josai University
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Yamazaki Tohru
Faculty Of Pharmaceutical Sciences Josai University
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Yamazaki Tohru
Faculty Of Enginering Himeji Institute Of Technology
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Hirose Akihiko
National Inst. Of Health Sciences (nihs)
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Mitsumoto Atsushi
Faculty Of Pharmaceutical Sciences Josai International University
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Ando Hiroshi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Sakamoto Takeshi
Faculty Of Pharmaceutical Sciences Josai University
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Kawashima Yoichi
Fac. Of Pharmaceutical Sciences Josai Univ.
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Kawashima Yoichi
Faculty Of Pharmaceutical Sciences Josai University
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Kawashima Yoichi
Faculty Of Pharmaceutical Science Josai University
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Hirose Akihiko
Division Of Risk Assessment Biological Safely Research Center National Institute Of Health Sciences
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