Role of Stearoyl-CoA Desaturase in the Modification of Acyl Composition of Hepatic Phosphatidylcholine by Peroxisome Proliferators
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概要
- 論文の詳細を見る
The relative contribution of stearoyl-CoA desaturase and 1-acylglycerophosphocholine (1-acyl-GPC) acyltransferase, which are induced by peroxisome proliferators, to the increase in the proportion of oleic acid in C-2 position of phosphatidylcholine (PtdCho) in the liver of rats was investigated. Rats were administered either 4-chlorophenoxyisobutyric acid (clofibric acid), 2,2'-(decamethylenedithio)-di-ethanol (tiadenol) or perfluorooctanoic acid in varying doses. With administration of these peroxisome proliferators, the proportion of oleic acid in C-2 position of PtdCho in hepatic microsomes was increased in commensurate with the increase in activities of stearoyl-CoA desaturase and 1-acyl-GPC acyltransferase. Multiple regression analysis revealed that although there is a high correlation among the three parameters examined, the partial correlation between the proportion of oleic acid in the C-2 position and the activity of stearoyl-CoA desaturase is significantly higher than that between the proportion of oleic acid in the C-2 position and the activity of 1-acyl-GPC acyltransferase. The contribution of stearoyl-CoA desaturase to the increase in the proportion of oleic acid in the C-2 position thus appears greater than that of 1-acyl-GPC acyltransferase.
- 公益社団法人日本薬学会の論文
- 1996-12-15
著者
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KAWASHIMA Yoichi
Faculty of Pharmaceutical Sciences, Josai University
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Kudo N
Josai Univ. Saitama Jpn
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Kudo Naomi
Faculty Of Pharmaceutical Science Josai University
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Mizuguchi Hiroki
Research Laboratories, Torii Pharmaceutical Co.,Ltd.
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Mizuguchi Hiroki
Research Laboratories Torii Pharmaceutical Co. Ltd.
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Kawashima Yoichi
Faculty Of Pharmaceutical Science Josai University
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MIZUGUCHI Hiroki
Research Laboratories, Torii Pharmaceutical Co., Ltd.,
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