Identification of Candidate Genes Determining Chemosensitivity to Anti-cancer Drugs of Gastric Cancer Cell Lines
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概要
- 論文の詳細を見る
In order to efficiently develop improved cancer therapies it is important to predict the efficacy of anti-cancer drugs. In this regard, identification of genes that are related to drug sensitivity is vital. We previously established a panel of 39 human cancer cell lines (JFCR39) and a panel aiming for organ-specific analysis of 45 human cancer cell lines (JFCR45). Here, we focus on 20 human gastric cancer cell lines from JFCR45, a panel of human cancer cell lines to predict genes that determine chemosensitivity to anti-cancer drugs. We measured both chemosensitivity to a range of anti-cancer drugs as well as changes in gene expression profile. We then identified genes in which expression is related to chemosensitivity by using a Pearson correlation. As a result, anti-cancer drugs that have similar mechanisms of action showed similar fingerprints against a gastric subpanel of human cancer cell lines, as was the case with JFCR39 and JFCR45. Furthermore, we identified many candidate genes related to the sensitivity of gastric cancer cells to anti-cancer drugs.
- 日本薬学会の論文
著者
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YAMORI Takao
Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Resea
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NAKATSU Noriyuki
Division of Cellular and Molecular Toxicology, BSRC, National Institute of Health Sciences
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Yamori Takao
Division Of Experimental Chemotherapy Cancer Chemotherapy Center Japanese Foundation For Cancer
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Nakamura Tomoki
Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Resea
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Yoshida Yoko
Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Resea
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Yamazaki Kanami
Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Resea
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Dan Shingo
Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Resea
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Sadahiro Soutaro
Second Department of Surgery, Tokai University School of Medicine
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Makuuchi Hiroyasu
Second Department of Surgery, Tokai University School of Medicine
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中津 則之
東大院農
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Yoshida Yoko
Division Of Molecular And Genetic Medicine Department Of Genetic Medicine And Regenerative Therapeut
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Dan Shingo
Division Of Molecular Pharmacology Cancer Chemotherapy Center Japanese Foundation For Cancer Researc
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Yamazaki Kanami
Division Of Molecular Pharmacology Cancer Chemotherapy Center Japanese Foundation For Cancer Researc
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Nakatsu Noriyuki
Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences
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Yoshida Yoko
Division Of Diabetes And Metabolism The Institute For Adult Diseases Asahi Life Foundation
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Nakatsu Noriyuki
Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
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Yoshida Yoko
Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
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