8-Hydroxydihydrochelerythrine and 8-Hydroxydihydrosanguinarine with a Potent Acetylcholinesterase Inhibitory Activity from Chelidonium majus L.(Pharmacognosy)
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概要
- 論文の詳細を見る
Ethanol extract of the aerial portion of Chelidonium majus L. inhibited acetylcholinesterase (AChE) activity without a significant inhibition of butyrylcholinesterase (BuChE). Using mass spectrometry and NMR studies, three active constituents were isolated and identified: 8-hydroxydihydrochelerythrine (1), 8-hydroxydihydrosanguinarine (2), and berberine (3). Compounds 1-3 showed potent inhibitory activity against AChE, with IC_<50> (μM) values of 0.61-1.85. Compound 1 exhibited competitive and selective inhibition for AChE.
- 公益社団法人日本薬学会の論文
- 2006-11-01
著者
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YOO Ick-Dong
Korea Research Institute of Bioscience and Biotechnology
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Kim Won-Gon
Korea Research Institute of Bioscience and Biotechnology
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Kim Won-gon
韓国
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Cho Kyung-mi
Korea Research Institute Of Bioscience And Biotechnology
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Yoo Ick-dong
Microbial Chemistry Research Group Korea Research Institute Of Bioscience & Biotechnology
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Yoo Ick-dong
Korea Res. Inst. Of Bioscience And Biotechnology
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Kim Won-gon
Functional Metabolomics Res. Center Korea Res. Inst. Of Bioscience And Biotechnology
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