Glioperazine B, as a New Antimicrobial Agent against Staphylococcus aureus, and Glioperazine C: Two New Dioxopiperazines from Bionectra byssicola

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概要

• 論文の詳細を見る

• In the course of our screening for new antibacterials from microbial metabolites, two new dioxopiperazine metabolites, glioperazines B (1) and C (2), together with the known compound, glioperazine (3), were isolated from the mycelia of a liquid fermentation culture of the fungus, Bionectra byssicola F120. The structures of compounds 1 and 2 were assigned on the basis of MS and NMR data. Compound 1 is an unusual dioxopiperazine metabolite containing an OMe group at the α-carbon of the amino acid residue. Compound 1 showed weak antibacterial activity against various strains of S. aureus, including methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), while 2 and 3 did not show such activity.

• 社団法人 日本農芸化学会の論文

著者

• Kim Won-Gon

  Korea Research Institute of Bioscience and Biotechnology

• Kim Won-gon

  Functional Metabolites Research Center Korea Research Institute Of Bioscience And Biotechnology

• KIM Young-Ho

  Chungnam National University, College of Pharmacy

• Zheng Chang-Ji

  Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology

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