Differential Antiviral Activity of Benzastatin C and Its Dechlorinated Derivative from Streptomyces nitrosporeus(Microbiology)
スポンサーリンク
概要
- 論文の詳細を見る
Benzastatin C, a 3-chloro-tetrahydroquinolone alkaloid from Streptomyces nitrosporeus, showed antiviral activity in a dose-dependant manner with EC_<50> values of 1.92, 0.53, and 1.99μg/ml against herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and vesicular stomatitis virus (VSV), respectively. In contrast, benzastatin D, the corresponding dechlorinated derivative, did not exhibit any antiviral activity. These results indicate that the antiviral activity of benzastatin C is mediated, in part, due to the chlorine moiety in its molecular structure.
- 公益社団法人日本薬学会の論文
- 2007-04-01
著者
-
Kim Won-gon
Functional Metabolites Research Center Korea Research Institute Of Bioscience And Biotechnology
-
YOO Ick-Dong
Functional Metabolomics Research Center, Korea Research Institute of Bioscience and Biotechnology
-
Won-gon Kim
Functional Metabolomics Research Center Korea Research Institute Of Bioscience And Biotechnology
-
Yoo Ick-dong
Functional Metabolomics Research Center Korea Research Institute Of Bioscience And Biotechnology
-
LEE Jong-Gyo
Pharmacology Research Center, Korea Research Institute of Chemical Technology
-
Lee Jong-gyo
Pharmacology Research Center Korea Research Institute Of Chemical Technology
関連論文
- Verticillin G, a New Antibacterial Compound from Bionectra byssicola
- Glioperazine B, as a New Antimicrobial Agent against Staphylococcus aureus, and Glioperazine C: Two New Dioxopiperazines from Bionectra byssicola
- A New Antioxidant, Clitocybin A, from the Culture Broth of Clitocybe aurantiaca
- Macrolactin S, a New Antibacterial Agent with FabG-inhibitory Activity from Bacillus sp. AT28
- Atromentin and Leucomelone, the First Inhibitors Specific to Enoyl-ACP Reductase (FabK) of Streptococcus pneumoniae
- Differential Antiviral Activity of Benzastatin C and Its Dechlorinated Derivative from Streptomyces nitrosporeus(Microbiology)
- Glioperazine B, as a New Antimicrobial Agent against Staphylococcus aureus, and Glioperazine C : Two New Dioxopiperazines from Bionectra byssicola
- Talosins A and B : New Isoflavonol Glycosides with Potent Antifungal Activity from Kitasatospora kifunensis MJM341 : II. Physicochemical Properties and Structure Determination