Isolation and Identification of FR198248, a Hydroxylated 1,3-Dihydroisobenzofuran, from Aspergillus flavipes as an Inhibitor of Peptide Deformylase
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概要
- 論文の詳細を見る
Two highly hydroxylated 1,3-dihydroisobenzofurans, FR198248 (1) and FR202306 (2), were isolated as peptide deformylase (PDF) inhibitors from Aspergillus flavipes. Compounds 1 and 2 inhibited Staphylococus aureus PDF with IC50 values of 3.6 and 2.5 μM, respectively, and also showed antibacterial activity with an MIC value of 25 μg/ml. In contrast, 6-O-methyl derivative 3 of compound 2 was inactive against both PDF and S. aureus.
- 社団法人 日本農芸化学会の論文
著者
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Kwon Yun-Ju
Korea Research Institute of Bioscience and Biotechnology
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Kim Won-Gon
Korea Research Institute of Bioscience and Biotechnology
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Zheng Chang-Ji
Korea Research Institute of Bioscience and Biotechnology
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