The Absolute Stereochemistry of Nebularine-Methanol Photoadduct. A Potential Transition-State Analog of Adenosine Deaminase

スポンサーリンク

概要

• 論文の詳細を見る

• A stereoselective photoaddition of methanol to nebularine and 2', 3', 5'-tri-O-acetylnebularine was investigated. The absolute stereochemistry of the nebularine-methanol photoadduct (2a), a potential transition-state analog of adenosine deaminase, was determined to be 6 (S) by X-ray analysis. The addition site of methanol on the purine ring was also chemically demonstrated to be at C (6).

• 社団法人日本薬学会の論文
• 1983-09-25

著者

• 飯高 洋一

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• 飯高 洋一

  帝京大・医

• 大野 雅二

  Faculty of Pharmaceutical Science, University of Tokyo

• 大野 雅二

  (present Address)eisai Co. Ltd.

• 島崎 正美

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 中村 光

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 島崎 正美

  Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)biochemical Research Laborat

• 大野 雅二

  東京大学:エーザイ(株)研究開発本部

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

関連論文

• Chemical and Chemotaxonomical Studies of Filices. LXXI. Chemical Studies on the Constituents of Cheiropleuria bicuspis (BL.) PR.(Organic,Chemical)
• Chemistry of Tremorogenic Metabolites. II. Structure Determination of Fumitremorgin B, a Tremorogenic Metabolite from Aspergillus fumigatus
• The Constituents of Schizonepeta tenuifolia BRIQ. I. Structures of Two New Monoterpene Glucosides, Schizonepetosides A and B
• The Revised Stereostructure of Patrinoside X-Ray Crystallographic Analysis
• RING TRANSFORMATION OF AN ISOXAZOLINE-1-OXIDE. A NOVEL TRANSFORMATION PRODUCT, DIMETHYL 7-CHLORO-3a, 4-DIHYDRO-5aH-BENZOFURO [3,3a-d] ISOXAZOLE-3,4-DICARBOXYLATE
• Studies on the Terpenoids and Related Alicyclic Compounds. XXI. Formation and X-Ray Crystal Structure of a Novel Spiro Dimer of 6-Dehydroxysantoninic Acid
• ISOLATION AND STRUCTURAL DETERMINATION OF MUTAGENIC SUBSTANCES IN COAL TAR
• REACTION OF ORGANOMETALLIC REAGENTS WITH 2'- AND 3'-KETOURIDINE DERIVATIVES : SYNTHESIS OF URACIL NUCLEOSIDES BRANCHED AT THE 2'- AND 3'-POSITIONS(Communications to the Editor)
• Synthesis of 1,2,3-Triazine N-Oxides
• THE STRUCTURE OF 1,2,3-TRIAZINE
• THE STRUCTURE OF 1,2,3-TRIAZINE
• ADDITION REACTION OF 1,2,3-TRIAZINE 2-IMINES WITH DIMETHYL ACETYLENEDICARBOXYLATE
• THE STRUCTURE AND ABSOLUTE CONFIGURATION OF HANAMISINE
• THE STRUCTURE AND ABSOLUTE CONFIGURATION OF SADOSINE
• THE STRUCTURE OF IGNAVINE
• A Potent Mutagen isolated from a Pyrolysate of L-Ornithine
• A Potent Mutagen isolated from a Pyrolysate of L-Ornithine
• Chetracin A and Chaetocins B and C, Three New Epipolythiodioxo-piperazines from Chaetomium spp.
• Biologically Active Constituents of Magnolia salicifolia : Inhibitors of Induced Histamine Release from Rat Mast Cells
• STUDIES ON THE ANTITUMOR CYCLIC HEXAPEPTIDES OBTAINED FROM RUBIAE RADIX
• Palladium (II) Chelates of 1,1-Dimethyl-3-(4-methyl-2-thiazolyl) thiourea and Related Thioureas
• The Formation of Cyclic Peroxide from Guaia-6,9-diene as a Model for Hanalpinol Biosynthesis
• FORMATION OF N, 1-BIS [5-(3-PHENYL)-[1,2,4] OXADIAZOLYL] DIMETHYLAMINES
• The Absolute Stereochemistry of Nebularine-Methanol Photoadduct. A Potential Transition-State Analog of Adenosine Deaminase
• The Molecular and Crystal Structures of Two Derivatives of a Sesterterpene, Ophiobolin D
• Synthetic Studies on Marasmane and iso-Marasmane Derivatives
• The Structure of Lucidusculine and the Absolute Configuration of Songorine
• Antitumor Activity of Shikonin, Alkannin and Their Derivatives. II. X-Ray Analysis of Cyclo-alkannin Leucoacetate, Tautomerism of Alkannin and Cyclo-alkannin and Antitumor Activity of Alkannin Derivatives
• Studies on Metal Complexes of Isocytosine Derivatives : The Molecular Structures of Platinum(II)and Platinum(IV)Complexes of 2-Hydrazino-4-hydroxy-6-methylpyrimidine
• Studies on the Chemical Constituents of Lilium henryi BAKER
• Chemische und Chemotaxonomische Untersuchungen der Pterophyten. LXII. : Chemische Untersuchungen der Inhaltsstoffe von Arachniodes maximowiczii OHWI
• Studies on Organic Fluorine Compounds. XLVII. Synthesis of Trifluoromethylated Sugars through the Aldol Reaction of 2-Trimethylsilyloxy-4-trifluoromethylfuran
• Structure of (+)-Epigriseofulvin
• Products of the Nitration of 2-Thiazolylureas and 2-Thiazolylthioureas
• Studies on the Constituents of Xanthoceras sorbifolia BUNGE. II. Major Sapogenol and a Prosapogenin from the Fruits of Xanthoceras sorbifolia BUNGE
• Ring Transformation of a Diterpenoid Grayanol Derivative into 1-epi-Leucothol
• Studies on Fungal Products. VII. The Structures of Meleagrin and 9-O-p-Bromobenzoylmeleagrin
• The Chemical Constituents of Ajuga Plants. I. neo-Clerodanes from the Leaves of Ajuga nipponensis MAKINO
• 4,4-Dimethyl Effect. (4). The Conformation of α-Onoceradienedione in the Crystalline State
• Studies on the Relationship between Physico-chemical Properties and Crystalline Forms of Tulobuterol Hydrochloride. II. Crystal Structure Analyses of the Four Crystalline Forms of Tulobuterol Hydrochloride
• Chemical and Chemotaxonomical Studies of Ferns. XXXVI. Crystallographic Studies of Pterokaurene L_2 and Pteroatisene P_2
• Reaction of Grayanotoxin-II with Lead Tetraacetate
• Chemische und chemotaxonomische Untersuchungen von Filices. XXXIV. Chemische Untersuchungen der Inhaltsstoffe von Pteris purpureorachis COPEL.
• Chemische und chemotaxonomische Untersuchungen von Filices. XXXIII. Chemische Untersuchungen der Inhaltsstoffe von Pteris longipes DON.
• Absolute Configurations of Chaetochromin A and Related Bis(naphtho-γ-pyrone) Mold Metabolites(Organic,Chemical)
• Reaction of Pyridoxal with Cyanide
• NOVEL QUASSINOIDS FROM EURYCOMA LONGIFOLIA
• C-Glycosyl Nucleosides. VI. Synthesis and Crystal Structure of Dithiane Glycoside Analog
• THREE NOVEL NAPHTHOHYDROQUINONE DIMERS FROM RUBIA ONCOTRICHA
• NEW TRITERPENOIDS FROM RUBIA CORDIFOLIA VAR. PRATENSIS (RUBIACEAE)
• Inhibition of Prostaglandin Biosynthesis by 4-O-Methylcryptochlorophaeic Acid ; : Synthesis of Monomeric Arylcarboxylic Acids for Inhibitory Activity Testing and X-Ray Analysis of 4-O-Methylcryptochlorophaeic Acid
• A Fungal Metabolite, Novel Isocyano Epoxide
• The Crystal Structure of the Bromoacetylated Dimer-A synthesized by the Reaction of Acridine with Hydroxylamine-O-sulfonic Acid
• ELUCIDATION OF THE STRUCTURES OF OLIVORETIN B AND C
• Structures and Solid State Tautomeric Forms of Two Novel Antileukemic Tropoloisoquinoline Alkaloids, Pareirubrines A and B, from Cissampelos pareira
• THE ABSOLUTE CONFIGURATION AND CONFORMATION OF NEOCURDIONE
• Studies on the Mechanism of the Voges-Proskauer Reaction The Crystal Structure of Pigment A'
• Studies on Tetrahydroisoquinolines. XXIII. Reactions of (±)-7-Acetoxy-7-methoxy-1-(3,4-dimethoxy-or 3,4-methylenedioxybenzyl)-2-methyl-6-oxo-Δ^-hexahydroisoquinoline (o-Quinol Acetate)
• Studies on Tetrahydroisoquinolines. XXI. A Synthesis of (±)-1-Hydroxy-2-methoxyhomoproaporphine and Stereochemistry of 4-Oxygenated 1,2,3,4-Tetrahydroisoquinolines
• A PARTIAL SYNTHESIS OF ISOMULTIFLORENOL FROM DENDROPANOXIDE
• Structure of the Endoperoxides derived from Vitamin D Derivatives by Dye Sensitized Photo-oxidation : X-Ray Crystal Structure of 6,19-Epidioxy-9,10-seco-5 (10), 7,22-ergostatrien-3β-ol Benzoate
• Reaction of Phenanthrene-9,10-oxide with Tetracyanoethylene
• A Novel Pseudotwistane, Pulchellon from Gaillardia pulchella
• Structure of Paragracine, A Biological Active Marine Base from Parazoanthus gracilis (Lwowsky)
• A New Fluorometric Analysis of Dulcin using Sodium Nitrite. III. Structural Determination of the Fluorescent Compound by the Single Crystal X-Ray Diffraction Method
• Isolation and Structural Analysis of a Fluorescent Compound produced by the Reaction of Dulcin with Sodium Nitrite
• Hongconin, a New Naphthalene Derivative from Hong-Cong, the Rhizome of Eleutherine ameicana MERR. et HEYNE(Iridaceae)
• A New Alkaloid, Croomine, from Croomia heterosepala OKUYAMA
• RENEWED STUDIES ON THE STRUCTURE OF DIDYMIC ACID
• Peptides in Higher Plants. II. The Crystal Structure of Tri-N-methylfrangulanine Methiodide
• Novel Sesquiterpenes from Alpinia intermedia GAGNEP.(Pharmacognosy,Chemical)
• Novel Guaiane- and Secoguaiane-Type Sesquiterpenes from Alpinia japonica(THUNB.) MIQ.(Pharmacognosy,Chemical)
• Structures of Torilolide and Oxytorilolide; Two Novel Germacranolides from Torilis japonica (HOUTT.) DC.
• A Novel Sesquiterpene Peroxide from Alpinia japonica (THUNB.) MIQ.
• Agarofuran-, Eudesmane-and Eremophilane-Type Sesquiterpenoids from Alpinia japonica (THUNB.) MIQ.
• Isolation of Agarofuran-type Sesquiterpenes from Alpinia japonica (THUNB.) MIQ.
• Mechanism of the Millon Reaction. II. The Crystal Structure of Pigment 1
• Studies on Lupin Alkaloids. VIII. A New Stereoisomer of Sophocarpine
• Microbiologically Modified Chiral Synthon. II. : 4,9-Dimethyl-3,7-dioxo-Δ^-octalin for Formal Total Syntheses of Certain C(8) Oxygenated Sesquiterpenoids
• Microbiologically Modified Chiral Synthon. I. 3,8-Dioxo-4-methoxycarbonyl-9-methyl-Δ^-octalin for Formal Total Syntheses of Certain Sesquiterpenoids and Diterpenoids
• MICROBIOLOGICALLY MODIFIED 4,9-DIMETHYL-Δ^-OCTAL-3,7-DIONES AS THE CHIRAL SYNTHON FOR FORMAL TOTAL SYNTHESES OF C(8) OXYGENATED SESQUITERPENOIDS(Communications to the Editor)
• MICROBIOLOGICAL ASYMMETRIC REDUCTION OF 4-CARBOMETHOXY-3,8-DIOXO-9-METHYL-Δ^-OCTALIN
• The Complete Structure of Spathulin, a Crystallographic Study of Diacetylspathulin
• NEW BISABOLANE SESQUITERPENOIDS FROM THE RHIZOMES OF CURCUMA XANTHORHIZA (ZINGIBERACEAE) II
• Chemical Studies on the Oriental Plant Drugs. XXXVI. Structure of Licoricone, a New Isoflavone from Licorice Root
• Biologically Active Constituents of Arnebia euchroma : Structures of New Monoterpenylbenzoquinones : Arnebinone and Arnebifuranone
• Biologically Active Constituents of Arnebia euchroma : Structure of Arnebinol, an Ansa-Type Monoterpenylbenzenoid with Inhibitory Activity on Prostaglandin Biosynthesis
• THE STEREOSTRUCTURE OF WENJINE AND RELATED (1S__-, 10S__-), (4S__-, 5S__-)-GERMACRONE-1(10), 4-DIEPOXIDE ISOLATED FROM CURCUMA WENYUJIN
• THE ABSOLUTE CONFIGURATION OF REGELIDINE, A NOVEL 6-NICOTINOYL DIHYDROAGAROFURAN SESQUITERPENE ALKALOID FROM TRIPTERYGIUM REGELII(Communications to the Editor)
• ISOLATION AND STRUCTURE OF REGELIN AND REGELINOL, NEW ANTITUMOR URSENE-TYPE TRITERPENOIDS FROM TRIPTERYGIUM REGELII(Communication to the Editor)
• Structure of Gilvanol, a New Triterpene isolated from Quercus gilva BLUME
• A NOTE ON THE A-RING CONFORMATION IN 2-CHLORO-1,2-DIHYDROSANTONINS
• EQUILIBRATION OF 2-CHLORO-1,2-DIHYDROSANTONIN CONFORMERS : A THEORETICAL APPROACH USING X-RAY DIFFRACTION AND MO CALCULATIONS
• Chemical and Chemotaxonomical Studies of Ferns. XXXI. Chemical Studies on the Constituents of Arachinoides standishii OHWI
• Chemische Untersuchungen der Inhaltsstoffe von Arachinoides standishii OHWI
• Studies on Metal Complexes of Isocytosine Derivatives : The Crystal Structure of Copper (II) Complex of 2-Hydrazino-4-hydroxy-6-methylpyrimidine
• The Constituents of Schizandra chinensis BAILL. II. The Structure of a New Lignan, Gomisin D
• Studies on the Chlorinated α-Santonins. II. The Crystal and Molecular Structure of 14-Chlorosantonin
• Crystal Structure of facial-[Bis-(adeninato) (diethylenetriamine)-copper (II)] Monohydrate
• Stereochemistry of Macrolides. II. Crystal Structure of p-Bromobenzoylpikromycin

もっと見る 閉じる

スポンサーリンク