Syntheses of the Acridone Alkaloid Citrusinine-I and Its Derivatives
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概要
- 論文の詳細を見る
Citrusinine-I (1), a naturally occurring acridone alkaloid with potent anitiviral activity, was synthesized for the first time, via a route involving Ulmann reaction, cyclization, and selective demethylation at the 1-position with boron trifluoride etherate and lithium bromide. 1,5,6-Trihydroxy-3-methoxy-9(10H)-acridone (2a) and 1,5,6-trihydroxy-3-methoxy-10-methyl-9(10H)-acridone (2b) were also synthesized.
- 社団法人日本薬学会の論文
- 1993-03-15
著者
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西山 幸廣
Laboratory Of Virolygy Research Institute For Disease Mechanism And Control Nagoya University School
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加藤 信治
Central Research Laboratories, Santen Pharmaceutical Co., Ltd.,
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藤田 昌宣
Central Research Laboratories, Santen Pharmaceutical Co., Ltd.,
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藤村 健一
Central Research Laboratories, Santen Pharmaceutical Co., Ltd.,
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河嶋 洋一
Central Research Laboratories, Santen Pharmaceutical Co., Ltd.,
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河嶋 洋一
Central Research Laboratories Santen Pharmaceutical Co. Ltd.
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藤田 昌宣
Central Research Laboratories Santen Pharmaceutical Co. Ltd.
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加藤 信治
Central Research Laboratories Santen Pharmaceutical Co. Ltd.
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藤村 健一
Central Research Laboratories Santen Pharmaceutical Co. Ltd.
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