Thiol Compounds. III. Synthesis and Antihypertensive Activity of Mercaptoacylamino Acids
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概要
- 論文の詳細を見る
A series of mercaptoacylamino acids containing tyrosine, dopa and α-methyldopa moieties is reported, and the structure-activity relationships are discussed. These compounds were tested for antihypertensive activity, and some of the compounds exhibited inhibitory activity against angiotensin I-converting enzyme. N-(2-Mercaptopropanoyl)-L-tyrosine-b (6b) was found to be 5 times more potent than N-(2-mercaptopropanoyl)-L-phenylalanine-a (Ia).
- 社団法人日本薬学会の論文
- 1981-05-23
著者
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大矢 正雪
Research Laboratory Santen Pharmaceutical Co. Ltd.
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松本 順三
Research Laboratory, Santen Pharmaceutical Co., Ltd.
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岩尾 順一
Research Laboratory, Santen Pharmaceutical Co., Ltd.
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河嶋 洋一
Central Research Laboratories, Santen Pharmaceutical Co., Ltd.,
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岩尾 順一
Central Research Laboratories Santen Pharmaceutical Co. Ltd.
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松本 順三
Research Laboratory Santen Pharmaceutical Co. Ltd.
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河嶋 洋一
Central Research Laboratories Santen Pharmaceutical Co. Ltd.
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河嶋 洋一
Research Laboratory, Santen Pharmaceutical Co., Ltd.
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加藤 栄信
Research Laboratory, Santen Pharmaceutical Co., Ltd.
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加藤 榮信
Research Laboratory Santen Pharmaceutical Co. Ltd.
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加藤 栄信
参天製薬
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