Synthesis of Hydrazone Derivatives of 3a, 4-Dihydroadrenochrome-3a-sulfides and Determination of Their Hemostatic Activities
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概要
- 論文の詳細を見る
The addition reaction between thiols and adrenochrome at 25℃ yielded trans-3a, 4-dihydroadrenochrome-3a-sulfides (3-5), which were treated with hydrazides to give hydrazones (6-10). On the other hand, the reaction of adrenochrome with β-mercaptopropionic acid at 5℃, followed by treatment with benzoylhydrazine, gave cis-3a-(β-carboxyethylthio)-3a, 4-dihydroadrenochrome monobenzoylhydrazone (11) as the main product. These hydrazones were tested for hemostatic effect. The hydrazone with the most potent hemostatic activity was 7.
- 社団法人日本薬学会の論文
- 1981-07-25
著者
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大矢 正雪
Research Laboratory Santen Pharmaceutical Co. Ltd.
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岩尾 順一
Research Laboratory, Santen Pharmaceutical Co., Ltd.
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岩尾 順一
Central Research Laboratories Santen Pharmaceutical Co. Ltd.
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磯 正
Research Laboratory, Santen Pharmaceutical Co., Ltd.
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宇田 弘三
参天製薬
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磯 正
Central Research Laboratories Santen Pharmaceutical Co. Ltd.
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加藤 栄信
Research Laboratory, Santen Pharmaceutical Co., Ltd.
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宇田 弘三
Research Laboratory, Santen Pharmaceutical Co., Ltd.
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藤田 公司
Research Laboratory, Santen Pharmaceutical Co., Ltd.
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加藤 榮信
Research Laboratory Santen Pharmaceutical Co. Ltd.
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加藤 栄信
参天製薬
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藤田 公司
Research Laboratory Santen Pharmaceutical Co. Ltd.
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