Iodoplatinate によるポストカラム配位子交換反応を用いる有機硫黄化合物の高速液体クロマトグラフィー. : アンギオテンシン変換酵素阻害剤(2R, 4R)-2-(o-Hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidinecarboxylic Acid (SA446) とその尿中代謝物の同時定量への応用(生物学及び生化学)

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The reactivity of iodoplatinate with 36 compounds was surveyed. Most of organosulfur compounds such as thiols, disulfides, thioethers, thioketones and compounds having thiazolidine ring reacted with colored iodoplatinate to result in decoloration. However, compounds which contain organosulfur in the molecule as sulfoxide or sulfone group gave weak or no decoloration. Iodoplatinate also reacted with such reductants as nicotinamide adenine dinucleotide phosphate, nicotinamide adenine dinuclaotide and L-ascorbic acid. For the simultaneous determination of (2R, 4R)-2-(o-hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidinecarboxylic acid (SA446), a thiol group containing angiotensin converting enzyme inhibitor, and its urinary metabolites, the reaction was applied to the postcolumn detection after high performance liquid chromatography (HPLC). Iodoplatinate may be expected as a useful reagent for the postcolumn reaction in HPLC determination of organosulfur compounds and some reductants in biological samples.
公益社団法人日本薬学会の論文
1986-11-25