Thiol Compounds. II. Synthesis and Antihypertensive Activity of Mercaptoacylamino Acids
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概要
- 論文の詳細を見る
The synthesis and structure-activity relationship of a series of mercaptoacylamino acids are described. These compounds were tested for antihypertensive activity. When the compounds were screened as angiotensin I-converting enzyme inhibitors in vitro, N-(2-mercaptopropanoyl)-L-cysteine-a (7a) and N^2-(2-mercaptopropanoyl)-L-tryptophan-a (20a) were found to be 10 and 20 times more active than tiopronin, respectively.
- 社団法人日本薬学会の論文
- 1981-04-25
著者
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大矢 正雪
Research Laboratory Santen Pharmaceutical Co. Ltd.
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松本 順三
Research Laboratory, Santen Pharmaceutical Co., Ltd.
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高階 秀男
Research Laboratory, Santen Pharmaceutical Co., Ltd.
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岩尾 順一
Research Laboratory, Santen Pharmaceutical Co., Ltd.
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岩尾 順一
Central Research Laboratories Santen Pharmaceutical Co. Ltd.
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高階 秀男
参天製薬株式会社研究部
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渡辺 敏郎
Research Laboratory, Santen Pharmaceutical Co., Ltd.
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渡辺 敏郎
Research Laboratory Santen Pharmaceutical Co. Ltd.
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松本 順三
Research Laboratory Santen Pharmaceutical Co. Ltd.
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