Thiol Compounds. V. Absolute Configuration and Crystal Structure of (4R)-2-(2-Hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidinecarboxylic Acid
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概要
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The absolute configuration of (4R)-2-(2-hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidinecarboxylic acid (11a), SA 446,which has a potent inhibitory activity against angiotensin I-converting enzyme (ACE), was determined to be (2R, 4R) by nuclear magnetic resonance (NMR) spectroscopy, specific rotation measurement and X-ray crystallography. The structure-activity relationships of the (2R, 4R)-and (2S, 4R)-isomers are discussed, and stereoselective acylation of (4R)-2-aryl-4-thiazolidinecarboxylic acids (1-3) is also described.
- 社団法人日本薬学会の論文
- 1982-02-25
著者
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大矢 正雪
Research Laboratory Santen Pharmaceutical Co. Ltd.
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安岡 則武
Institute For Protein Research Osaka University.
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岩尾 順一
Research Laboratory, Santen Pharmaceutical Co., Ltd.
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岩尾 順一
Central Research Laboratories Santen Pharmaceutical Co. Ltd.
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加藤 栄信
Research Laboratory, Santen Pharmaceutical Co., Ltd.
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加藤 榮信
Research Laboratory Santen Pharmaceutical Co. Ltd.
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加藤 栄信
参天製薬
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