Synthesis and Antihypertensive Activity of N-(Mercaptoacyl)-thiazolidinecarboxylic Acids
スポンサーリンク
概要
- 論文の詳細を見る
The synthesis and antihypertensive activity of a new series of N-(mercaptoacyl)-thiazolidinecarboxylic acids (VIIa-d) are described. Antihypertensive activity was evaluated in terms of angiotensin I-converting enzyme (ACE) inhibitory activity. The activities of these compounds were compared with that of (2S)-1-[(2S)-3-mercapto-2-methylpropanoyl] proline, SQ 14225,and many of them were found to be relatively potent inhibitors of ACE. The most potent was (4R)-2-(2-hydroxyphenyl)-3-(3-mercaptopropanoyl)-4-thiazolidinecarboxylic acid (62). Structure-activity relationships among the thiazolidines and some related compounds are discussed.
- 社団法人日本薬学会の論文
- 1982-02-25
著者
-
大矢 正雪
Research Laboratory Santen Pharmaceutical Co. Ltd.
-
河嶋 洋一
Central Research Laboratories, Santen Pharmaceutical Co., Ltd.,
-
渡辺 敏郎
Research Laboratory, Santen Pharmaceutical Co., Ltd.
-
渡辺 敏郎
Research Laboratory Santen Pharmaceutical Co. Ltd.
-
河嶋 洋一
Central Research Laboratories Santen Pharmaceutical Co. Ltd.
-
馬場 俊夫
Research Laboratory, Santen Pharmaceutical Co., Ltd.
-
河嶋 洋一
Research Laboratory, Santen Pharmaceutical Co., Ltd.
-
加藤 栄信
Research Laboratory, Santen Pharmaceutical Co., Ltd.
-
加藤 榮信
Research Laboratory Santen Pharmaceutical Co. Ltd.
-
加藤 栄信
参天製薬
-
馬場 俊夫
Research Laboratory Santen Pharmaceutical Co. Ltd.
関連論文
- Thiol Compounds. I. Synthesis and Antihypertensive Activity of Mercaptoacylamino Acids
- Syntheses of the Acridone Alkaloid Citrusinine-I and Its Derivatives
- Thiol Compounds. II. Synthesis and Antihypertensive Activity of Mercaptoacylamino Acids
- Synthesis and Aldose Reductase Inhibitory Activity of N-Acylthiazolidinecarboxylic Acids
- Synthesis and Calcium Antagonistic Activity of (+)-(R)- and (-)-(S)-3-Acetyl-2-[5-methoxy-2-[4-[N-methyl-N-(3,4,5-trimethoxyphenethyl)amino]butoxy]phenyl]benzothiazoline Hydrochloride
- Synthesis and Antihypertensive Activity of 5-(2-Hydroxyphenyl)-1-(3-mercaptopropionyl)-2-pyrrolidinecarboxylic Acids
- Synthesis and Aldose Reductase Inhibitory Activity of Thiazolidinecarboxylic Acids Containing a Disulfide Bond
- Mass Spectrometry of 2-Alkylthio-2-methylpropanoic Acids and Their Esters and Amides. Structural and Steric Effects on the McLafferty Rearrangement
- Conformational Studies of Semotiadil (SD-3211), a Novel Ca^ Antagonist
- Conversion of Thiols into Disulfides with Diethyl Bromomalonate
- Thiol Compounds. VI. Mass Spectra of (2R, 4R)-2-(2-Hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidinecarboxylic Acid and Related Compounds
- Thiol Compounds. V. Absolute Configuration and Crystal Structure of (4R)-2-(2-Hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidinecarboxylic Acid
- Synthesis and Antihypertensive Activity of N-(Mercaptoacyl)-thiazolidinecarboxylic Acids
- Synthesis of Hydrazone Derivatives of 3a, 4-Dihydroadrenochrome-3a-sulfides and Determination of Their Hemostatic Activities
- Thiol Compounds. III. Synthesis and Antihypertensive Activity of Mercaptoacylamino Acids
- アンジオテンシン変換酵素阻害剤の合成と薬効 (「医薬品開発をめぐる生理活性物質の合成」特集号)
- New Sulfhydryl Compounds with Potent Antihypertensive Activities
- Synthesis and Pharmacological Activities of Novel Cyclic Disulfide and Cyclic Sulfide Derivatives as Hepatoprotective Agents
- Synthesis of Thiazolidine-2-thione Derivatives and Evaluation of Their Hepatoprotective Effects
- Molecular Mechanics Study on the Folded Conformation of Semotiadil, a Ca^ Antagonist Having a Benzothiazine Skeleton
- Chiroptical and Conformational Studies of Optically Active 2-Aryl-2H-1,4-benzothiazin-3(4H)-one Derivatives, Related Compounds with a Novel Ca^ Antagonist, Semotiadil (SD-3211)