水晶体の構造特性と薬物反応(第1報)水晶体1価カチオンレベルにおよぼす白内障惹起物質の影響

概要

論文の詳細を見る
In order to know the biochemical evidence concerning structural characteristics of the lens, rat lens was incubated in the divided chamber which can separate anterior and posterior regions from each other, and the cataractogenic effects of ouabain, diamide, nigericin and ethylene glycol bis (β-aminoethylether)-N, N, N', N'-tetraacetic acid (EGTA) on Na^+ and K^+ contents in the lens were studied by adding these compounds either to the medium facing the anterior side or to the posterior side of the lens. Application of ouabain and diamide at the anterior side caused an increase of Na^+ and a loss of K^+, and the Na^+/K^+ value of this application was higher than that at the posterior side of the lens. In contrast, nigericin and EGTA caused cation changes independently of the side applied. These results may be related to the mode of action of such cataractogenic agents that the former two compounds act on lens by decreasing the activity of cation pump localized at the anterior surface of the lens, and the latter two compounds by increasing membrane permeability of cations.
公益社団法人日本薬学会の論文
1982-10-25