Syntheses of Heterocyclic Compounds involving Sulfur. I. Syntheses of 1,3-Dihydro-2H-pyrimido [5,6,1-kl] phenothiazine, 1,2-Dihydro-3H-pyrazino [3,2,1-kl] phenothiazine and 1,2-Dihydroimidazo- [4,5,1-kl] phenothiazine

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概要

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• Reaction of 1-tosylaminomethylphenothiazine (VI) and methylene iodide gave 2-tosyl-1,3-dihydro-2H-pyrimido [5,6,1-kl] phenothiazine (VII). 3-Tosyl-1,2-dihydro-3H-pyrazino- [3,2,1-kl] phenothiazine (XIV) or 2-tosyl-1,2-dihydroimidazo [4,5,1-kl] phenothiazine (XVIII) was synthesized from 1-tosylaminophenothiazine (XIII) and ethylene bromide or methylene iodide. Detosylation of VII, XIV, and XVIII gave 1,3-dihydro-2H-pyrimido [5,6,1-kl] -phenothiazine (VIII), 1,2-dihydro-3H-pyrazino [3,2,1-kl] phenothiazine (XII), and 1,2-dihydroimidazo [4,5,1-kl] phenothiazine (XVII), respectively. In addition, syntheses of these new four-ringed nitrogen heterocycles were studied by other routes.

• 公益社団法人日本薬学会の論文
• 1970-10-25

著者

• 青山 豊彦

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 白井 秀明

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 早崎 孝則

  名古屋市立大学薬学部

• 早崎 孝則

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 早崎 孝則

  Faculty Of Pharmaceutical Sciences Kyoto University

• 青山 豊彦

  Faculty Of Pharmaceutical Sciences Nagoya City University

関連論文

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