Synthesis of Spiro [4-hydroxycyclohexane-1,4'-2', 3'-dihydro-6'-methoxy-2'-methyl-1'H-isoquinoline] and 4-Dimethylaminomethyl-4-(m-methoxyphenyl) cyclohexanol
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概要
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For the purpose of testing the biological activity, spiro-[4-hydroxycyclohexane-1,4'-2', 3'-dihydro-6'-methoxy-2'-methyl-1'H-isoquinoline] (IV) was synthesized by cyclization of 1-(m-methoxyphenyl)-4-hydroxycyclohexanemethylamine (XIII), which was obtained from the trans-acetoxy-amide (XII), in the presence of excess formic acid and formaldehyde under the conditions of Eschweiler-Clarke reaction. 4-Dimethylaminomethyl-4-(m-methoxyphenyl) cyclohexanol (V) was synthesized by reduction of 1-(m-methoxyphenyl)-4-acetoxycyclohexanecarbonyl dimethylamide (XIV), which was obtained from the trans-acetoxy-acid chloride (XI), with lithium aluminum hydride.
- 社団法人日本薬学会の論文
- 1975-09-25
著者
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八代 有
Faculty of Pharmaceutical Sciences Nagoya City University
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山田 恭子
Faculty of Pharmaceutical Sciences, Nagoya City University
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白井 秀明
Faculty of Pharmaceutical Sciences, Nagoya City University
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山田 恭子
Faculty Of Pharmaceutical Sciences Nagoya City University
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