The Behavior of 1,4-Benzodiazepine Drugs in Acidic Media. III. Carbon-13 Nuclear Magnetic Resonance Spectra of Flutazolam in Acidic Aqueous Solution
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概要
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Structural changes of flutazolam in acidic aqueous solution were investigated by using proton and carbon-13 nuclear magnetic resonance spectroscopy. Flutazolam underwent a rapid cleavage of the oxazolidine ring to form an iminium compound, followed by slow hydrolysis of the iminium bond to give a benzophenone compound, like other 1,4-benzodiazepinooxazoles. Neutralization of the flutazolam solution caused recycling, which was not found in the case of other compounds that had no substituent at the nitrogen atom in position 7. The carbon-13 resonances of these compounds and of the corresponding aminobenzophenone derivatives isolated under strongly acidic conditions were assigned.
- 公益社団法人日本薬学会の論文
- 1985-10-25
著者
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八代 有
Faculty of Pharmaceutical Sciences Nagoya City University
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八代 有
名古屋市立大学薬学部
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桑山 知成
Pharmacy, NTT Tokai General Hospital
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桑山 知成
Pharmacy Ntt Tokai General Hospital
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