1,4-Benzodiazepine系医薬品の酸性水溶液中における挙動(第7報)Flurazepamの酸性水溶液中でのCarbon13核磁気共鳴スペクトル
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概要
- 論文の詳細を見る
Chemical species of flurazepam in an acidic aqueous solution (0.5 N DCl) were studied by means of carbon-13 nuclear magnetic resonance (^<13>C-NMR) spectroscopy. Flurazepam was present in the form of a protonated iminium structure immediately after preparation of the solution, and subsequently underwent hydrolysis of the iminium moiety to give a ring-opened benzophenone structure, which was in equilibrium with the ring-closed iminium structure. The proportion of the benzophenone structure in the equilibrium solution was greater than that of the iminium structure. The carbon-13 signals of these compounds and of the corresponding aminobenzophenone derivatives isolated under strongly acidic conditions were assigned.
- 公益社団法人日本薬学会の論文
- 1987-04-25
著者
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加藤 節子
名古屋市立大学薬学部
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八代 有
名古屋市立大学薬学部
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桑山 知成
Pharmacy, NTT Tokai General Hospital
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八代 有
名古屋市立大学
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桑山 知成
東海逓信病院薬剤科
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桑山 知成
Pharmacy Ntt Tokai General Hospital
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