1,4-Benzodiazepine系医薬品の酸性水溶液中における挙動(第9報)Flutazolamの加水分解生成物の中枢作用

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概要

• 論文の詳細を見る

• Effects of hydrolizate (III・HCl) of Flutazolam (I) on the antianxiety, the anticonvulsion, the prolongation of the sleep, the muscle relaxation and the antihypoxia were compared with I in mice by the established methods. It was demonstrated that III・HCl inhibited the anxiety and pentetrazol-induced convulsion, prolonged the thiopental-induced sleep, and produced the skeletal muscle relaxation and the protection against hypobaric-hypoxia. These potencies of III・HCl were equipotent to I. These results suggested that III・HCl might be able to be delivered in an injection form.

• 公益社団法人日本薬学会の論文
• 1987-10-25

著者

• 八代 有

  名古屋市立大学薬学部

• 桑山 知成

  Pharmacy, NTT Tokai General Hospital

• 八代 有

  名古屋市立大学

• 桑山 知成

  東海逓信病院薬剤科

• 川面 博

  三井製薬工業株式会社生物科学研究所

• 鈴木 孝昌

  三井製薬工業株式会社生物科学研究所

• 桑山 知成

  Pharmacy Ntt Tokai General Hospital

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