Kinetics and Mechanism of Reversible Hydrolysis of 11b-Methylbenzodiazepinooxazoles
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概要
- 論文の詳細を見る
Reversible hydrolyses of benzodiazepinooxazoles having an 11b-methyl group and of oxazolam having a 7-methyl group were investigated kinetically in buffers of various pH's and at 25℃, in the light of the light of the difference in the reversibility of the hydrolysis between 11b-methyl- and 11b-phenyl- (e.g., oxazolam itself) benzodiazepinooxazoles. The irreversibility of the hydrolysis of 11b-phenylbenzodiazepinooxazoles is considered to arise from the larger size of the phenyl group than the methyl group in addition to the intramolecular hydrogen bonding between carbonyl oxygen of benzophenone and amide hydrogen at the ortho position. Substituents at the 2-position of 11b-methylbenzodiazepinooxazole do not greatly affect the reversible hydrolysis.
- 公益社団法人日本薬学会の論文
- 1988-07-25
著者
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黒野 幸久
神戸大学 大学院医学系研究科精神神経科学分野
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池田 憲
名古屋市立大学薬学部
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池田 憲
Faculty Of Pharmaceutical Sciences Nagoya City University
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八代 有
Faculty of Pharmaceutical Sciences Nagoya City University
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八代 有
名古屋市立大学薬学部
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黒野 幸久
Faculty of Pharmaceutical Sciences, Nagoya City University
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桑山 知成
Pharmacy, NTT Tokai General Hospital
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神野 康弘
Faculty of Pharmaceutical Sciences, Nagoya City University
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八代 有
名古屋市立大学
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桑山 知成
Pharmacy Ntt Tokai General Hospital
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神野 康弘
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd.,
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神野 康弘
Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.
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