Galanthamine Chemistry. VII. Synthesis of Analogues of Galanthamine

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概要

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• 4-Acetoxy-7'-methoxyspiro[cyclohexane-1,1' (2'H)-naphthalen]-4'(3'H)-one (XXIV) has been synthesized and subjected to the Schmidt reaction to give the isomeric benzaze-pinones (XXV and XXVI). N-methylation followed by reduction with lithium aluminum hydride of these compounds (XXV and XXVI) afforded the 1-and 2-benzazepine (II and III), respectively. In contrast to the inhibitory effect of galanthamine (I) on acetylcholinesterase, neither of these two synthetics showed appreciable anticholinesterase activity.

• 公益社団法人日本薬学会の論文
• 1966-09-25

著者

• 八代 有

  Faculty of Pharmaceutical Sciences Nagoya City University

• 影井 健吾

  Tsukuba Research Laboratories, Eisai Co., Ltd.,

• 神代 昭

  Faculty Of Pharmaceutical Sciences Kyoto University

• 上尾 庄次郎

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• 影井 健吾

  Tsukuba Research Laboratories Eisai Co. Ltd.

• 白井 秀明

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 上尾 庄次郎

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• 影井 健吾

  Faculty of Pharmaceutical Sciences, Kyoto University

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