溶液製剤における分子間相互作用 : 薬物の溶解性の向上, 分配並びに安定性
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The pharmaceutical studies carried out by the author during 40 years were reviewed from the viewpoint of molecular interaction. Included subjects are : electrostatic interaction between drug ions, ion pair formation and its partition to organic phase, drug solubilization by adjuvants, partition of drugs between aqueous and micellar phases, cyclodextrin inclusions, human serum albumin binding and drug stability related to the esterase-like activity of the albumin, and oral liposome preparation of vitamin K_1. The drug stabilities related to those molecular interactions were emphasized.
- 公益社団法人日本薬学会の論文
- 1992-05-25
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