Studies on Decomposition and Stabilization of Drugs in Solution. I. Chemical Kinetic Studies on Aqueous Solution of Phenobarbital.
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概要
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The degradative reaction of phenobarbital was investigated over a pH range of 6.0 to 10.5 from the standpoint of chemical kinetics and the following results were obtained. 1) The degradation is an apparent unimolecular reaction at any fixed pH value and is in itself a bimoleculer reaction catalyzed by hydroxyl ion. The presence of any catalysis besides that by hydroxyl ion is not recognized. The relation between log k and pH is given in Fig. 4. 2) The results obtained well agreed with Eq. (8) which is derived from the postulation described in the theoretical consideration. As seen in Table III, the velocity constant k_1 (molecular form) is larger than k_2 (ionized form), but the decomposition depends on the concentration of hydroxyl ion, and hydrolysis in an alkaline region is very much accelerated. 3) The velocity constant k_2 was slightly smaller than that calculated and further investigation may be necessary for the elucidation of this reason.
- 公益社団法人日本薬学会の論文
- 1958-02-20
著者
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長谷川 淳
Faculty Of Pharmaceutical Sciences University Of Tokyo
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池田 憲
Faculty Of Pharmaceutical Sciences Nagoya City University
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長谷川 淳
Pharmaceutical Development, Ayerst Laboratories, Inc.
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池田 憲
Pharmaceutical Institute Medical Faculty University Of Tokyo
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松沢 兌
Pharmaceutical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
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