Studies on Absorption and Excretion of Drugs. I. Kinetics of Penetration of Acidic Drug, Salicylic Acid, through the Intestinal Barrier in vitro.
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概要
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1. A penetration of salicylic acid through the rat small intestine was investigated from the standpoint of chemical kinetics in vitro. 2. Theoretical equations were derived from the assumption that the intestinal barrier was partially permeable to both the undissociated and dissociated forms of the drug. 3. From the data obtained, the respective permeability coefficients for the undissociated and dissociated forms of salicylic acid, P_u and P_i, were statistically determined. The estimated value of P_u was 0.0125 (cc./cm./min.) and that of P_i 0.00233 (cc./cm./min.). 4. As there was a little difference between the observed and the calculated values, an experiment at the equilibrium state was tried for the purpose of elucidating the cause of the difference. 5. The results indicate that salicylic acid is transferred across the intestinal barrier with specific coefficient for both forms of drug, P_u and P_i, that the ratio for P_u/P_i is about 6,and the relative rapid penetration of the dissociated form can be attributed to the above ratio.
- 公益社団法人日本薬学会の論文
- 1961-07-25
著者
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野上 寿
Faculty Of Pharmaceutical Sciences University Of Tokyo
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松沢 兌
Pharmaceutical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
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松沢 兌
Faculty of Pharmaceutical Sciences, University of Tokyo
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