Studies on Decomposition and Stabilization of Drugs in Solution. III. Chemical Kinetic Studies on Aqueous Solution of 2-Diethylaminoethyl Diphenylglycolate Methobromide
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概要
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1. It was evidenced by the ultraviolet absorption spectral analyses that the decomposition of 2-diethylaminoethyl diphenylglycolate methobromide in aqueous solution is the hydrolysis of ester linkage. 2. The determination of 2-diethylaminoethyl diphenylglycolate methobromide was carried out, separating it from its decomposed substances, by a colorimetric procedure using ethylene dichloride and bromocresol purple in a buffer solution of pH 6.5. 3. The decomposition was recognized as a first-order reaction and catalyzed by hydrogen ion, hydroxyl ion, and water. The constants were determined as follows : [numerical formula] [numerical formula]
- 1958-06-20
著者
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野上 寿
Faculty Of Pharmaceutical Sciences University Of Tokyo
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中島 徳保
Faculty Of Pharmaceutical Sciences University Of Tokyo
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