Studies on Absorption and Excretion of Drug. XIII. The Sorption of Surface Active Agents into the Intestinal Tissue of Rat and Their Effect on the Drug Absorption in Vitro

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概要

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• 1) The sorption of ionic surfactants (sodium lauryl sulfate, cetyltrimethylammonium bromide) into the intestinal tissue of the rat and the effect of sodium lauryl sulfate on the drug absorption were investigated above and below critical micelle concentration from the standpoint of kinetics in vitro. 2) The sorption of the surfactant into the intestinal tissue was concluded to follow the first order kinetics below critical micelle concentration, and the zero order kinetics above it. 3) The observed zero order rate constants were slightly larger than the calculated values in sodium lauryl sulfate and particularly cetyltrimethylammonium bromide. 4) The micelle formation of sodium lauryl sulfate decreased the absorption of nitrobenzene which distributed to the micelle. But the absorption of o-methoxybenzaldehyde which did not distribute to the micelle was not influenced by the micelle formation of surfactant.

• 公益社団法人日本薬学会の論文
• 1968-11-25

著者

• 長谷川 淳

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 花野 学

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 野上 寿

  東京大学薬学部

• 野上 寿

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 花野 学

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 野上 寿

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 不破 享

  Faculty Of Pharmaceutical Sciences University Of Tokyo

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