Solubilization of dl-α-Tocopherol by Bile Salts, Polysorbate 80 and Egg Lecithin
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概要
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The solubilization dl-α-tocopherol (VE) into micellar solutions of bile components and non-ionic polysorbate 80 (PS-80) was studied. Dihydroxy conjugated bile salt showed a higher saturation ratio than trihydroxy conjugated bile salt. The mixed micelles of bile salt with egg lecithin (PC) solubilized more VE than the bile salt alone. PS-80 micelles showed a saturation ratio approximately 20 times higher than those of bile salts. When PC was included in PS-80micellar solution, the solubility of VE decreased with increasing PC content. The order of micellar size of bile salts and PS-80 solubilizing VE, as measured by gel filtration, was sodium taurocholate, sodium taurodeoxycholate and PS-80.
- 公益社団法人日本薬学会の論文
- 1983-11-25
著者
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花野 学
Faculty of Pharmaceutical Sciences, University of Tokyo
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粟津 荘司
Faculty of Pharmaceutical Sciences, University of Tokyo
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粟津 荘司
東京薬科大学薬学部 薬物動態制御学教室
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花野 学
Faculty Of Pharmaceutical Sciences University Of Tokyo
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林 正弘
Faculty of Pharmaceutical Sciences, University of Tokyo
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今井 淳
Faculty of Pharmaceutical Sciences, University of Tokyo
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今井 淳
Faculty Of Pharmaceutical Sciences University Of Tokyo
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