水溶性薬物の消化管吸収 : 主として吸収促進について

概要

論文の詳細を見る
Intestinal absorption of water-soluble drugs are mainly discussed from the paracellular route absorption. The phenomena of drug absorption enhancement are reviewed mainly by the authors' works. The pores on intestinal membrane can be divided into two kinds at least. One is the pore which allows a molecular with larger molecular radius like that of PEG900 or inulin to pass its paracellular route, and the other is the pore which allows only a small molecule like glycerol to pass. Colonic membrane is liable to be affected by the absorption enhancers, while jejunal membrane is much less liable. These findings are ascertained by drug permeation technique and electrophysiological technique as well. And the authors stated that colon and rectum could be more effective for water-soluble drug absorption which is promoted by absorption enhancers than jejunum.
日本医療薬学会の論文