Relationship between the Morphological Character of 5-Nitroacetyl-salicylic Acid Crystals and the Decomposition Rate in a Humid Environment
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概要
- 論文の詳細を見る
Two morphologically different crystals, column-shaped and ramified, were sorted under a microscope from a recrystallized batch of 5-nitroacetylsalicylic acid. Their degradation rates in the solid state were quantitatively studied and the progress of decomposition was observed under a polarizing microscope. Plots of the ratio decomposed against the reaction time were sigmoidal under all reaction conditions, and Avrami's kinetic equation was applicable to this reaction below 40% degradation. The reactivity of the ramified crystals was greater than that of the column-shaped crystals under all experimental conditions. Although the parameter B of Avrami's equation, which is assumed theoretically to be proportional to the product of the number of latent reaction nuclei and the voluminal growth rate varied by a factor of 10^4 at maximum under various experimental conditions, the ratio of B between ramified and column-shaped crystals remained fairly constant under all the conditions tested, and was about five. The results of observation of the decomposing crystals under a polarizing microscope agreed well with Avrami's theory of the formation and growth of reaction nuclei.
- 公益社団法人日本薬学会の論文
- 1980-02-25
著者
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花野 学
Faculty of Pharmaceutical Sciences, University of Tokyo
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粟津 荘司
Faculty of Pharmaceutical Sciences, University of Tokyo
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粟津 荘司
東京薬科大学 薬
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花野 学
Faculty Of Pharmaceutical Sciences University Of Tokyo
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岡村 信
Faculty Of Pharmaceutical Sciences The University Of Tokyo:(present Address)department Of Pharmacy C
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