Studies on Percutaneous Absorption. III. Kinetics of Percutaneous Absorption.
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概要
- 論文の詳細を見る
1) A diffusion model was presented on the percutaneous absorption from lipidinsoluble vehicle and the equation was derived in regard to the decrease in the rate of concentration of a drug applied : C/C_0=exp (-At/RV) where C_0 is the initial concentration of a drug, C the concentration at time t, R the over-all resistance, V the volume of vehicle, and A the area applied. The relation between the rate of decrease and the degree of dissociation of a drug was also expressed from the same model : C/C_0=exp (-At (1-a)/RV) where a is the degree of dissociation. 2) Both equations were proved to be conformable to the absorption of salicylic and benzoic acids from the aqueous and buffer solutions through the intact human skin.
- 公益社団法人日本薬学会の論文
- 1959-05-10
著者
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花野 学
Faculty of Pharmaceutical Sciences, University of Tokyo
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花野 学
Faculty Of Pharmaceutical Sciences University Of Tokyo
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