Various Factors affecting Intestinal Absorption of Iodochlorhydroxyquin in Rat and Man

概要

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Various factors affecting the intestinal absorption of iodochlorhydroxyquin (I), which is remarked in relation to SMON (subacute myelo-optico-neuropathy), were investigated. From urinary excretion data in rats, it was found that the excretion ratio to the dose studied was larger in the case of the low dose, but it seemed that the sodium carboxymethyl cellulose (CMC-Na) effect was more effective for the high dose. And from plasma concentration data in rats, the CMC-Na effect at the high dose was also recognized. Therefore considering that the dose dependent effect of CMC-Na was due to that the endogeneous suspending agent in digestive fluid, probably bile component, was enough to suspend I of the low dose, but not of the high dose, the effect of bile on the absorption of I by the method of bile or saline solution infusion into the duodenum of the bile fistula rat was further investigated. The result was that bile was more effective on the absorption than CMC-Na, and so bile could be well regarded as the endogeneous suspending agent. But urinary data of man showed that there were two types of man, sensitive and unsensitive for CMC-Na, and so its effect was not so obvious.
公益社団法人日本薬学会の論文
1976-11-25