Dammarane-Saponins of Sanchi-Ginseng, Roots of Panax notoginseng (BURK.) F.H. CHEN (Araliaceae) : Structures of New Saponins, Notoginsenosides-R1 and -R2,and Identification of Ginsenosides-Rg_2 and -Rh_1

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概要

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• From Sanchi-Ginseng, roots of Panax notoginseng cultivated in Yunnan, China, two new dammarane-saponins named notoginsenosides-R1 (5) and -R2 (7S) were isolated by means of reverse phase high performance liquid chromatography. The structures of these saponins were established as 20 (S)-protopanaxatriol 6-[O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranosyl]-20-O-β-D-glucopyranoside (5) and 20 (S)-protopanaxatriol 6-O-β-D-xylopyranosyl (1→2)-β-D-glucopyranoside (7S), respectively, mainly by ^<13>C NMR spectroscopy and mass spectrometry. In connection with this study, assignments of carbon signals of ginsenoside-Rf (11), a minor saponin of Ginseng roots, were substantiated by the application of selective deuteration of the sugar moiety as reported by Stuart et al. Besides these saponins, two known saponins, ginsenosides-Rh_1 (12) and -Rg_2 (13) which have previously been isolated from Ginseng roots, were also isolated and identified.

• 公益社団法人日本薬学会の論文
• 1981-10-25

著者

• 周 俊

  Kunming Institute of Botany, the Chinese Academy of Science

• 田中 治

  Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine

• 周 俊

  Kunming Institute Of Botany The Chinese Academy Of Science

• 不破 亨

  Central Research Lab., Wakunaga Pharmaceutical Co.

• 不破 亨

  Central Research Lab. Wakunaga Pharmaceutical Co.

• 田中 治

  丸善製薬

• 猿渡 雄一郎

  Central Reseach Laboratories, Wakunaga Pharmaceutical Co., Ltd.,

• 谷保 樹典

  Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine

• 伍 明珠

  Kunming Institute of Botany, Academia Sinica

• 別曽 広道

  Wakunaga Pharmaceutical Co., Ltd.

• 猿渡 雄一郎

  Wakunaga Pharmaceutical Co., Ltd.

• 不破 亨

  Wakunaga Pharmaceutical Co., Ltd.

• 猿渡 雄一郎

  Central Reseach Laboratories Wakunaga Pharmaceutical Co. Ltd.

• 田中 治

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

• 別曽 広道

  Central Research Laboratories, Wakunaga Pharmaceutical Co., Ltd.

• 別曽 広道

  Central Research Laboratories Wakunaga Pharmaceutical Co. Ltd.

• 谷保 樹典

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

• 伍 明珠

  Kunming Institute Of Botany Academia Sinica

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