98 中国産ウリ科生薬土貝母より得られる新サイクリックビスデスモサイドについて : 構造と溶解促進効果
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概要
- 論文の詳細を見る
An oleanane type triterpenoid glycoside, named Tubeimoside I (1) was isolated from rhizome of Bolbostemma paniculatum (Maxim.) Franquet. (Cucurbitaceae), a Chinese folk medicine, "Tu Bei Mu". The structure of 1 was revealed on the basis of the spectral and chemical evidences as shown in Scheme 1. The name, cyclic bisdesmoside is proposed for the glycoside of this type. It has been reported that the water solubility of the monodesmoside, saponin A from Sapindus mukurossi Gaertn. which causes remakable enhancement of the absorbtion of antibiotics from rat intestine and rectum, is greatly increased by the co-occurring bisdesmosides, mukurozi-saponin X,Y_1 and Y_2. It was observed that the solubilizing effect of the cyclic bisdesmoside 1 on saponin A as well as water insoluble Yellow OB was much more intense than the above mukurozi-saponins and the deacylated bisdesmoside (3). Studies on the chirality of 3-hydroxy-3-methyl-glutaric acid moiety of 1 and the other surfactive properties are under progress.
- 天然有機化合物討論会の論文
- 1985-09-07
著者
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宮腰 正純
丸善製薬(株)総合研究所
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周 俊
Kunming Institute of Botany, the Chinese Academy of Science
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笠井 良次
広島大薬
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宮腰 正純
広島大薬
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松本 一浩
広島大薬
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森田 俊信
広島大薬
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田中 治
広島大薬
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周 俊
昆明植物研
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笠井 良次
広島大・医
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松本 一浩
Central Research Laboratories, Asahi Breweries, Ltd,
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周 俊
Kunming Institute Of Botany The Chinese Academy Of Science
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松本 一浩
Central Research Laboratories Asahi Breweries Ltd
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森田 俊信
Central Research Laboratories Wakunaga Pharmaceutical Co. Ltd.
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