土貝母サイクリックビステスモシドの溶解促進及び包接作用
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概要
- 論文の詳細を見る
Tubeimosides I, II and III (cyclic bisdesmosides) have been isolated from Chinese cucurbitaceous crude drug Tu-bei-mu, a tuber of Bolbostemma paniculatum (MAXIM.) FRANQUET. Solubilizing effects of these cyclic bisdesmosides on water insoluble or lesssoluble compounds were examined. It was revealed that cyclic bisdesmosides were effective on increasing the solubility of Yellow OB, dl-α-tocopherol and saponin A from Sapindus mukurossi. The critical micell concentration (cmc) and association number as well as diameter of micell of tubeimoside I in water were also measured. The interaction of tubeimoside I with 1-anilino-8-naphthalene-sulfonate (ANS) in aqueous solution was investigated photometrically. It was observed that tubeimoside I strongly enhanced the intensity of fluorescence of ANS, suggesting the significant formation of inclusion complex.
- 社団法人日本薬学会の論文
- 1990-12-25
著者
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宮腰 正純
丸善製薬(株)総合研究所
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宮腰 正純
広島大学医学部総合薬学科
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笠井 良次
広島大学医学部総合薬学科
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西岡 誠
広島大学理学部化学科
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落合 洋
広島大学理学部化学科
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田中 治
広島大学医学部総合薬学科
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田中 治
広島大
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笠井 良次
広島大・医
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笠井 良次
広島大学医学部
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田中 治
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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田中 治
広島大学医学部
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