Studies on Mutagenicity of Swertiae Herba. III. : Components Which Become Mutagenic on Nitrite Treatment

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概要

• 論文の詳細を見る

• The methanolic extract of Swertiae Herba after treatment with nitrite was mutagenic to Salmonella typhimurium TA 98 in the absence of S9 mix. Two active principles were isolated and identified as amarogentin and amaroswerin, and this activity was proved to be associated with their 3,3', 5-trihydroxybiphenylcarboxylic acid moiety. 3,3'5-Trihydroxybiphenyl obtained from both the glucosides also exhibited mutagenicity after treatment with nitrite. Such activity was not observed for the non-acylated swecoiridoid glucosides and xanthone homologues of this drug.Quantitative analysis of the above two active glucosides in the commercial plant was also conducted.

• 公益社団法人日本薬学会の論文
• 1986-04-25

著者

• 田中 治

  Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine

• 田中 治

  広島大

• 金森 久幸

  広島県保健環境センター

• 金森 久幸

  Hiroshima Prefectural Institute of Public Health

• 坂本 征則

  Hiroshima Prefectural Institute of Public Health

• 水田 満里

  Hiroshima Prefectural Institute of Public Health

• 田中 治

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

• 坂本 征則

  広島県福祉保健部業務課

• 金森 久幸

  広島県保健環境セ

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